This review describes how a biochemist and basic researcher (i.e. myself) came to make a career in the area of receptor-coupled signal transduction and the roles cellular signaling activities play both in normal physiology and in disease. Much of what has been the best part of this research life is due to the time I spent with Bob Lefkowitz (1982–1985), during an extraordinary period in the emerging field of G-protein-coupled receptors. Among my laboratory colleagues were some truly outstanding scientists including Marc Caron, the late Jeffrey Stadel, Berta Strulovici, Jeff Benovic, Brian Kobilka, and Henrik Dohlman, as well as many more. I came to Bob's laboratory after being trained as a physical biochemist and enzymologist. Bob and his laboratory exposed me to a research style that made it possible to connect the kinds of fundamental biochemical and mechanistic questions that I loved to think about with a direct relevance to disease. Indeed, I owe Bob a great deal for having imparted a research style and philosophy that has remained with me throughout my career. Below, I describe how this has taken me on an interesting journey through various areas of cellular signaling, which have a direct relevance to the actions of one or another type of G-protein

这篇综述描述了生物化学家和基础研究人员（即我本人）如何在受体偶联信号转导领域取得成功，以及细胞信号转导活动在正常生理和疾病中的作用。这项研究生命中最美好的部分，大部分是由于我在鲍勃·莱夫科维茨（Bob Lefkowitz）（1982-1985）期间度过的，这是在新兴的G蛋白偶联受体领域的非凡时期。在我的实验室同事中，有一些真正杰出的科学家，包括马克·卡伦，已故的杰弗里·史塔德尔，贝塔·斯特罗洛维奇，杰夫·贝诺维奇，布莱恩·科比尔卡和亨里克·多尔曼，等等。在接受物理化学家和酶学家的培训后，我来到了鲍勃的实验室。鲍勃（Bob）和他的实验室向我展示了一种研究风格，使我喜欢思考的与生化直接相关的各种基本生化和机械问题成为可能。的确，我欠鲍勃很多，因为他传授了我整个职业生涯中一直存在的研究风格和哲学。在下文中，我将描述这是如何引导我进行细胞信号转导各个领域的有趣之旅，这些领域与一种或另一种G蛋白的作用直接相关