The ubiquitously expressed, multifunctional scaffolding proteins β-arrestin1 and β-arrestin2 each affect inflammatory signaling in a variety of cell lines. In addition to binding the carboxyl-terminal tails of innumerable 7-transmembrane receptors, β-arrestins scaffold untold numbers of other plasma membrane and cytoplasmic proteins. Consequently, the effects of β-arrestins on inflammatory signaling are diverse, and context-specific. This review highlights the roles of β-arrestins in regulating canonical activation of the pro-inflammatory transcription factor NFκB.

中文翻译：

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β-arrestins对炎症的调节：不仅是受体的故事

普遍表达的多功能支架蛋白β-arrestin1和β-arrestin2各自影响多种细胞系中的炎症信号传导。除了结合无数的7个跨膜受体的羧基末端尾巴以外，β-arrestins还支持其他数目的质膜和细胞质蛋白。因此，β-arrestin对炎症信号的影响是多种多样的，并且是针对特定环境的。这篇综述强调了β-arrestin在调节促炎性转录因子NFκB的规范激活中的作用。