Niclosamide is an oral antihelminthic drug used to treat parasitic infections in millions of people worldwide. However recent studies have indicated that niclosamide may have broad clinical applications for the treatment of diseases other than those caused by parasites. These diseases and symptoms may include cancer, bacterial and viral infection, metabolic diseases such as Type II diabetes, NASH and NAFLD, artery constriction, endometriosis, neuropathic pain, rheumatoid arthritis, sclerodermatous graft-versus-host disease, and systemic sclerosis. Among the underlying mechanisms associated with the drug actions of niclosamide are uncoupling of oxidative phosphorylation, and modulation of Wnt/β-catenin, mTORC1, STAT3, NF-κB and Notch signaling pathways. Here we provide a brief overview of the biological activities of niclosamide, its potential clinical applications, and its challenges for use as a new therapy for systemic diseases.

中文翻译：

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Niclosamide：除抗蠕虫药外。

Niclosamide是一种口服抗蠕虫药，用于治疗全球数百万人的寄生虫感染。但是，最近的研究表明，烟酰胺可能具有广泛的临床应用，可用于治疗由寄生虫引起的疾病以外的疾病。这些疾病和症状可能包括癌症，细菌和病毒感染，新陈代谢疾病，例如II型糖尿病，NASH和NAFLD，动脉收缩，子宫内膜异位，神经性疼痛，类风湿关节炎，硬皮移植物抗宿主病和全身性硬化症。与niclosamide的药物作用相关的潜在机制包括氧化磷酸化的解偶联和Wnt /β-catenin，mTORC1，STAT3，NF-κB和Notch信号通路的调节。在这里，我们简要概述了尼克洛酰胺的生物活性，