当前位置: X-MOL 学术Cell. Signal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Protein kinase C isoforms in the normal pancreas and in pancreatic disease
Cellular Signalling ( IF 4.8 ) Pub Date : 2017-08-18 , DOI: 10.1016/j.cellsig.2017.08.005
Alicia K. Fleming , Peter Storz

Protein Kinase C isoforms have been implicated in regulating multiple processes within the healthy pancreas. Moreover, their dysregulation contributes to all aspects of pancreatic disease. In this review, with a focus on acinar, ductal, and islet cells, we highlight the roles and contributions of the different PKC isoforms to normal pancreas function. We also discuss the contribution of PKC enzymes to pancreatic diseases, including insulin resistance and diabetes mellitus, as well as pancreatitis and the development and progression of pancreatic cancer.



中文翻译:

正常胰腺和胰腺疾病中的蛋白激酶C亚型

蛋白激酶C同工型与健康胰腺内的多个过程调控有关。此外,它们的失调导致胰腺疾病的各个方面。在这篇综述中,我们着重于腺泡,导管和胰岛细胞,我们重点介绍了不同PKC亚型对正常胰腺功能的作用和贡献。我们还讨论了PKC酶对胰腺疾病(包括胰岛素抵抗和糖尿病)以及胰腺炎以及胰腺癌的发生和发展的贡献。

更新日期:2017-08-18
down
wechat
bug