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Chiral surfaces: The many faces of chiral recognition
Current Opinion in Colloid & Interface Science ( IF 8.9 ) Pub Date : 2017-11-07 , DOI: 10.1016/j.cocis.2017.10.004
John C. Lang , Daniel W. Armstrong

Molecular recognition is integral to many biological, synthetic, and supramolecular systems. Recognition is often the nexus that controls the path, kinetics, and mechanism of chemical and biochemical processes. Recognition can be static in the case of more rigid molecular environments, or dynamic in which either the selector, selector target, or both respond altering conformations in response to the local environment, or the intended partner. The recognition may be simple, with just a pair interacting, or complex with multiple partners and the pairing can be concurrent or sequential. The partnering may be at an active site or in its vicinity where not only recognition occurs, but also subsequent chemical reactivity is regulated, or distant from that location yet altering the chemical architecture in a manner seeding longer-range consequences. Because it need involve relatively few dominant interactions and structural requirements, chiral recognition is often integral to the more intricate and complex concatenated influences on the chemical landscape. In this review we have identified several forms of chiral recognition, noted their efficacy can involve combinations of chirality, and have highlighted numerous functionalities that by their complementarity encompass a wide array of applications. We conclude by suggesting the variety of means available for regulating recognition.



中文翻译:

手性表面:手性识别的许多面孔

分子识别对于许多生物,合成和超分子系统都是必不可少的。识别通常是控制化学和生化过程的路径,动力学和机制的联系。在更严格的分子环境中,识别可以是静态的,也可以是动态的,其中选择器,选择器目标或两者都响应于局部环境或预期的配偶体而响应于改变的构象。识别可能很简单,只有一对相互作用,也可能与多个伙伴复杂,并且配对可以是并发的或顺序的。配偶体可以在活性位点或其附近,不仅发生识别,而且还调节随后的化学反应性,或者远离该位置,但以播种长期后果的方式改变化学结构。因为手性识别涉及相对较少的主要相互作用和结构要求,所以手性识别通常是对化学领域更为复杂和复杂的串联影响所不可或缺的。在这篇综述中,我们确定了几种手性识别形式,指出它们的功效可能涉及手性的组合,并强调了许多功能,这些功能的互补性涵盖了广泛的应用。最后,我们提出了各种可用于调节识别的手段。注意到它们的功效可能涉及手性的组合,并突出了众多功能,这些功能的互补性涵盖了广泛的应用。最后,我们提出了各种可用于调节识别的手段。注意到它们的功效可能涉及手性的组合,并突出了众多功能,这些功能的互补性涵盖了广泛的应用。最后,我们提出了各种可用于调节识别的手段。

更新日期:2017-12-14
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