Objectives

To conduct a cross-sectional morbidity survey among 245 former employees of a pesticide production plant exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in New Zealand.

Methods

Demographic factors and health information were collected in face-to-face interviews. TCDD, lipids, thyroid hormones, glucose and immunoglobulin G (IgG) were determined in non-fasting blood. For 111 participants, a neurological examination was conducted. Associations between health outcomes and working in a TCDD exposed job (prevalence 49%) and serum TCDD concentration ≥ 10 pg/g lipid (18%) were assessed using logistic regression whilst controlling for age, gender, smoking, body mass index and ethnicity.

Results

Diabetes was more common in those who had worked in TCDD exposed jobs (OR 4.0, 95%CI 1.0–15.4) and in those with serum TCDD ≥ 10 pg/g (OR 3.1, 95%CI 0.9–10.7). Non-fasting glucose levels > 6.6 mmol/l were more common in those with TCDD exposed jobs (OR 3.6, 95%CI 1.0–12.9), as were serum free thyroxine 4 < 12.8 pmol/l (OR 4.5, 95%CI 1.4–14.4), triglycerides > 1.7 mmol/l (OR 2.5, 95%CI 1.1–5.7) and high density lipoprotein cholesterol (HDL) < 1 mmol/l (OR 4.0, 95%CI 1.2–13.2). IgG was negatively associated with TCDD (linear regression p = 0.05). The neurological examination revealed a higher frequency of abnormal reflexes in those with serum TCDD ≥ 10 pg/g (OR 4.8, 95%CI 1.1–21.0).

Conclusions

In this occupationally exposed population, TCDD was associated with an increased risk of diabetes and a range of subclinical responses in multiple systems (peripheral nervous system, immune system, thyroid hormones and lipid metabolism), several decades after last exposure. These results need to be interpreted with caution due to the small study size and the cross-sectional nature of the study.

中文翻译：

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暴露于2,3,7,8-四氯二苯并-对二恶英（TCDD）的新西兰农药生产商的发病率

目标

进行中的农药生产厂受到2,3,7,8-四氯代245名离职员工的横截面发病率调查p在新西兰二氧杂环（TCDD）。

方法

在面对面的访谈中收集了人口统计学因素和健康信息。在非空腹血液中测定TCDD，脂质，甲状腺激素，葡萄糖和免疫球蛋白G（IgG）。对111名参与者进行了神经系统检查。健康结果和在TCDD工作暴露作业（患病49％）和血清TCDD浓度之间的关联 ≥  10 皮克/克脂肪（18％），使用逻辑回归，同时控制了年龄，性别，吸烟，身体质量指数和种族评估。

结果

糖尿病是多见于那些谁在TCDD暴露的工作职位（或4.0，95％CI 1.0-15.4），并在那些与血清TCDD≥  10 微克/克（或3.1，95％CI 0.9-10.7）。非空腹血糖水平>  6.6  mmol / l在暴露于TCDD的患者中更为常见（OR 3.6，95％CI 1.0-12.9），无血清甲状腺素4  <  12.8  pmol / l（OR 4.5，95 ％CI 1.4） –14.4），甘油三酸酯>  1.7  mmol / l（OR 2.5，95％CI 1.1–5.7）和高密度脂蛋白胆固醇（HDL）<  1  mmol / l（OR 4.0，95％CI 1.2-13.2）。IgG与TCDD呈负相关（线性回归p  =  0.05）。神经学检查发现反射异常的更高的频率在那些与血清TCDD≥  10 pg / g（或4.8，95％CI 1.1–21.0）。

结论

在这一职业暴露人群中，在上次暴露后数十年，TCDD与糖尿病风险增加以及多种系统（周围神经系统，免疫系统，甲状腺激素和脂质代谢）的一系列亚临床反应相关。由于研究规模小和研究的横断面性质，需要谨慎解释这些结果。