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Functionalization of single solid state nanopores to mimic biological ion channels: A review
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2017-09-14 , DOI: 10.1016/j.cis.2017.09.001
Mathilde Lepoitevin , Tianji Ma , Mikhael Bechelany , Jean-Marc Janot , Sebastien Balme

In nature, ion channels are highly selective pores and act as gate to ensure selective ion transport, allowing ions to cross the membrane. By mimicking them, single solid state nanopore devices emerge as a new, powerful class of molecule sensors that allow for the label-free detection of biomolecules (DNA, RNA, and proteins), non-biological polymers, as well as small molecules. In this review, we exhaustively describe the fabrication and functionalization techniques to design highly robust and selective solid state nanopores. First we outline the different materials and methods to design nanopores, we explain the ionic conduction in nanopores, and finally we summarize some techniques to modify and functionalize the surface in order to obtain biomimetic nanopores, responding to different external stimuli.



中文翻译:

单个固态纳米孔模拟生物离子通道的功能:综述。

实际上,离子通道是高度选择性的孔,并充当栅极以确保选择性的离子传输,从而允许离子穿过膜。通过模仿它们,单固态纳米孔装置成为一种新型的,功能强大的分子传感器,可对生物分子(DNA,RNA和蛋白质),非生物聚合物以及小分子进行无标记检测。在这篇综述中,我们详尽地描述了制造和功能化技术,以设计高度耐用和选择性的固态纳米孔。首先,我们概述了设计纳米孔的不同材料和方法,解释了纳米孔中的离子传导,最后总结了一些修饰和功能化表面的技术,以获得对仿生纳米孔的响应,以响应不同的外部刺激。

更新日期:2017-12-14
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