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Recent developments in drug eluting devices with tailored interfacial properties
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2017-05-04 , DOI: 10.1016/j.cis.2017.05.005
Eva Sanchez-Rexach , Emilio Meaurio , Jose-Ramon Sarasua

Drug eluting devices have greatly evolved during past years to become fundamental products of great marketing importance in the biomedical field. There is currently a large diversity of highly specialized devices for specific applications, making the development of these devices an exciting field of research. The replacement of the former bare metal devices by devices loaded with drugs allowed the sustained and controlled release of drugs, to achieve the desired local therapeutic concentration of drug. The newer devices have been “engineered” with surfaces containing micro- and nanoscale features in a well-controlled manner, that have shown to significantly affect cellular and subcellular function of various biological systems. For example, the topography can be structured to form an antifouling surface mimicking the defense mechanisms found in nature, like the skin of the shark. In the case of bone implants, well-controlled nanostructured interfaces can promote osteoblast differentiation and matrix production, and enhance short-term and long-term osteointegration. In any case, the goal of current research is to design implants that induce controlled, guided, and rapid healing. This article reviews recent trends in the development of drug eluting devices, as well as recent developments on the micro/nanotechnology scales, and their future challenges. For this purpose medical devices have been divided according to the different systems of the body they are focused to: orthopedic devices, breathing stents, gastrointestinal and urinary systems, devices for cardiovascular diseases, neuronal implants, and wound dressings.



中文翻译:

具有定制界面特性的药物洗脱设备的最新发展

在过去的几年中,药物洗脱设备已经得到了很大的发展,已成为在生物医学领域具有重要营销意义的基本产品。当前,针对特定应用的高度专业化的设备种类繁多,这些设备的开发成为令人兴奋的研究领域。用装有药物的装置代替以前的裸机装置可以使药物持续和受控释放,以达到所需的局部药物治疗浓度。较新的设备已经过“精心设计”,其表面以可控的方式包含了微米级和纳米级的特征,这些表面已显着影响各种生物系统的细胞和亚细胞功能。例如,地形可以构造成形成防污表面,模仿鲨鱼皮肤等自然界发现的防御机制。对于骨植入物,控制良好的纳米结构界面可以促进成骨细胞分化和基质产生,并增强短期和长期的骨整合。无论如何,当前研究的目的是设计诱导受控,引导和快速愈合的植入物。本文回顾了药物洗脱设备发展的最新趋势,以及微/纳米技术规模的最新发展及其未来的挑战。为此,医疗设备已根据其关注的身体不同系统进行了划分:骨科设备,呼吸支架,胃肠道和泌尿系统,心血管疾病设备,

更新日期:2017-12-14
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