Soft assemblies obtained following the Layer-by-Layer (LbL) approach are accounted among the most interesting systems for designing biomaterials and drug delivery platforms. This is due to the extraordinary versatility and flexibility offered by the LbL method, allowing for the fabrication of supramolecular multifunctional materials using a wide range of building blocks through different types of interactions (electrostatic, hydrogen bonds, acid-base or coordination interactions, or even covalent bonds). This provides the bases for the building of materials with different sizes, shapes, compositions and morphologies, gathering important possibilities for tuning and controlling the physico-chemical properties of the assembled materials with precision in the nanometer scale, and consequently creating important perspective for the application of these multifunctional materials as cargo systems in many areas of technological interest. This review studies different physico – chemical aspects associated with the assembly of supramolecular materials by the LbL method, paying special attention to the description of these aspects playing a central role in the application of these materials as cargo platforms for encapsulation and release of active compounds.

按照分层（LbL）方法获得的软装配被认为是设计生物材料和药物输送平台最有趣的系统之一。这是由于LbL方法提供了非凡的多功能性和灵活性，从而允许通过不同类型的相互作用（静电，氢键，酸碱或配位相互作用，甚至甚至是相互作用）使用多种结构单元来制造超分子多功能材料。共价键）。这为构建具有不同尺寸，形状，组成和形态的材料提供了基础，为以纳米级精度精确地调节和控制组装材料的物理化学特性提供了重要的可能性，因此，为将这些多功能材料用作货物系统在许多技术领域的应用创造了重要的前景。这篇综述研究了与通过LbL方法组装超分子材料有关的不同理化方面，并特别注意这些方面的描述，这些方面在将这些材料用作封装和释放活性化合物的货物平台中发挥着核心作用。