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Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents
Advances in Colloid and Interface Science ( IF 15.6 ) Pub Date : 2017-04-18 , DOI: 10.1016/j.cis.2017.04.006
Angelina Angelova , Vasil M. Garamus , Borislav Angelov , Zhenfen Tian , Yawen Li , Aihua Zou

The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.



中文翻译:

用于大分子药物,植物化学物质和抗肿瘤药物的脂质基纳米载体的结构设计研究进展

本工作着重介绍了用于药物递送应用的纳米结构分散体和生物胶体的开发方面的最新成就。我们强调生物小角度X射线散射(BioSAXS)研究在纳米药物设计中的关键作用。重点放在以脂质为基础的纳米载体中小分子植物化学药物的可控包封,以及在纳米结构的纳米颗粒中大分子siRNA,质粒DNA,肽和蛋白质药物的包封,可提供有效的细胞内递送和触发的药物释放。利用BioSAXS方法表征各种类型的液晶纳米组织(脂质体,海绵体,立方体,六体,鉴于植物化学物质和治疗性生物分子在纳米载体的疏水或亲水部分中的成功封装和保护,讨论了纳米脂质体和纳米结构脂质载体。我们得出结论,纳米颗粒载体的结构设计对于治疗结果和从生物胶体触发的药物释放至关重要。

更新日期:2017-12-14
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