-
Endothelial deubiquinatase YOD1 mediates Ang II-induced vascular endothelial-mesenchymal transition and remodeling by regulating β-catenin Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-19 Wan-te Lin, Yu-cheng Jiang, Yi-lin Mei, Yang-hao Chen, Zhao-zheng Zheng, Xue Han, Gao-jun Wu, Wei-jian Huang, Bo-zhi Ye, Guang Liang
-
Cpd-A1 alleviates acute kidney injury by inhibiting ferroptosis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-19 Ying Chen, Ming-fei Wu, Man-man Xie, Yang Lu, Chao Li, Shuai-shuai Xie, Wen-xian Ma, Ming-lu Ji, Rui Hou, Ze-hui Dong, Ruo-bing He, Meng-meng Zhang, Hao Lu, Li Gao, Jia-gen Wen, Juan Jin, Xiao-wu Dong, Jin-xin Che, Xiao-ming Meng
-
Liver receptor homolog-1: structures, related diseases, and drug discovery Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-17 Tong Wu, Zhi-fang Lu, Hao-nan Yu, Xi-shan Wu, Yang Liu, Yong Xu
-
Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-17 Hui-yu Liu, Xiao-jiao Sun, Si-yu Xiu, Xiang-yu Zhang, Zhi-qi Wang, Yan-lun Gu, Chu-xiao Yi, Jun-yan Liu, Yu-song Dai, Xia Yuan, Hua-peng Liao, Zhen-ming Liu, Xiao-cong Pang, Tian-cheng Li
-
Ripretinib inhibits HIV-1 transcription through modulation of PI3K-AKT-mTOR Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-16 Jin-feng Cai, Jia-sheng Zhou, Zhuo-yue Meng, Zi-qi Wu, Jia-cong Zhao, Hai-xiang Peng, Xin-yu Liang, Jun-jian Chen, Pei-pei Wang, Kai Deng
-
Transcriptional regulation and post-translational modifications in the glycolytic pathway for targeted cancer therapy Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-15 Xuan Ni, Cheng-piao Lu, Guo-qiang Xu, Jing-jing Ma
-
Novel STAT3 oligonucleotide compounds suppress tumor growth and overcome the acquired resistance to sorafenib in hepatocellular carcinoma Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-12 Qi-yi Zhang, Wen Ding, Jian-shan Mo, Shu-min Ou-yang, Zi-you Lin, Ke-ren Peng, Guo-pin Liu, Jin-jian Lu, Pei-bin Yue, Jin-ping Lei, Yan-dong Wang, Xiao-lei Zhang
-
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-12 Zhi-feng Zou, Lei Yang, Hui-jun Nie, Jing Gao, Shu-min Lei, Yi Lai, Fan Zhang, Ernst Wagner, Hai-jun Yu, Xiao-hua Chen, Zhi-ai Xu
-
A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-11 Hui-fang Zong, Xi Li, Lei Han, Lei Wang, Jun-jun Liu, Ya-li Yue, Jie Chen, Yong Ke, Hua Jiang, Yue-qing Xie, Bao-hong Zhang, Jian-wei Zhu
-
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-11 Gu-fang Zhang, Kai-lian Zhu, Qi Li, Yue Zhang, John L. Waddington, Xiang-dong Du, Xue-chu Zhen
-
Neutrophil extracellular traps promote acetaminophen-induced acute liver injury in mice via AIM2 Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Fan-le Zeng, Yuan Zhang, Zhong-hao Wang, Hui Zhang, Xue-teng Meng, Yi-qin Wu, Zhen-zhen Qian, Yu-hao Ding, Jun Li, Tao-tao Ma, Cheng Huang
-
Empagliflozin and liraglutide ameliorate HFpEF in mice via augmenting the Erbb4 signaling pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Xia-yun Ni, Xiao-jun Feng, Zhi-hua Wang, Yang Zhang, Peter J. Little, Yang Cao, Suo-wen Xu, Li-qin Tang, Jian-ping Weng
-
Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Luo-xing Xia, Ying-ying Xiao, Wen-jing Jiang, Xiang-yu Yang, Hua Tao, Safur Rehman Mandukhail, Jian-feng Qin, Qian-rong Pan, Yu-guang Zhu, Li-xin Zhao, Li-juan Huang, Zhan Li, Xi-yong Yu
-
Inhibition of USP7 enhances CD8+ T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Lin-lin Sun, Li-na Zhao, Jiao Sun, Hong-feng Yuan, Yu-fei Wang, Chun-yu Hou, Pan Lv, Hui-hui Zhang, Guang Yang, Ning-ning Zhang, Xiao-dong Zhang, Wei Lu
-
Prebiotic diet normalizes aberrant immune and behavioral phenotypes in a mouse model of autism spectrum disorder Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Naika Prince, Lucia N Peralta Marzal, Anastasia Markidi, Sabbir Ahmed, Youri Adolfs, R Jeroen Pasterkamp, Himanshu Kumar, Guus Roeselers, Johan Garssen, Aletta D Kraneveld, Paula Perez-Pardo
-
Indoxyl sulphate-TNFα axis mediates uremic encephalopathy in rodent acute kidney injury Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-08 Ling Jiang, Xue-ying Sun, Si-qian Wang, Yan-lin Liu, Ling-jue Lu, Wen-han Wu, Hao Zhi, Zhong-yan Wang, Xiao-dong Liu, Li Liu
Acute kidney injury (AKI) is often accompanied by uremic encephalopathy resulting from accumulation of uremic toxins in brain possibly due to impaired blood-brain barrier (BBB) function. Anionic uremic toxins are substrates or inhibitors of organic anionic transporters (OATs). In this study we investigated the CNS behaviors and expression/function of BBB OAT3 in AKI rats and mice, which received intraperitoneal
-
A novel role of PSMB9 in endothelial cells and atherosclerosis: beyond its canonical function in immunoproteasome Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-03 Xiaolei Liu, Esteban Delgado
The ubiquitin-proteasome system (UPS) constitutes a highly conserved protein degradation system in eukaryotic cells [1], comprising ubiquitin, ubiquitin enzymes, the 26 S proteasome, and deubiquitinating enzymes. The ubiquitin-proteasome degradation process involves a cascade reaction, in which proteins undergoing ubiquitination are ultimately degraded by the 26 S proteasome. This proteasome comprises
-
PBPK-PD model for predicting morphine pharmacokinetics, CNS effects and naloxone antagonism in humans Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-03 Rui-jing Mu, Tian-lei Liu, Xiao-dong Liu, Li Liu
Morphine and morphine-6-glucuronide (M6G) produce central nervous system (CNS) effects by activating mu-opioid receptors, while naloxone is used mainly for the reversal of opioid overdose, specifically for the fatal complication of respiratory depression, but also for alleviating opioid-induced side effects. In this study we developed a physiologically-based pharmacokinetic-pharmacodynamic (PBPK-PD)
-
Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-04-02 Shu-qi Huang, Kai-xiang Cao, Cai-ling Wang, Pei-ling Chen, Yi-xin Chen, Yu-ting Zhang, Shi-hui Yu, Zai-xia Bai, Shuai Guo, Mu-xi Liao, Qiao-wen Li, Guo-qi Zhang, Jun He, Yi-ming Xu
Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that undergo constant fusion and fission and are critical signalling hubs that modulate angiogenesis by coordinating reactive oxygen species (ROS) production and calcium signalling and metabolism. In this
-
ROCK1 inhibition improves wound healing in diabetes via RIPK4/AMPK pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-27 Tianru Huyan, Lu Fan, Zhong-yuan Zheng, Jing-hui Zhao, Zhen-ru Han, Pin Wu, Qun Ma, Ya-qin Du, Yun-di Shi, Chun-yan Gu, Xue-jun Li, Wen-hui Wang, Long Zhang, Lu Tie
-
Radiofrequency radiation reshapes tumor immune microenvironment into antitumor phenotype in pulmonary metastatic melanoma by inducing active transformation of tumor-infiltrating CD8+ T and NK cells Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-27 Jia-zheng Jiao, Yang Zhang, Wen-juan Zhang, Min-di He, Meng Meng, Tao Liu, Qin-long Ma, Ya Xu, Peng Gao, Chun-hai Chen, Lei Zhang, Hui-feng Pi, Ping Deng, Yong-zhong Wu, Zhou Zhou, Zheng-ping Yu, You-cai Deng, Yong-hui Lu
-
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-27 Pei Yang, Yang Liu, Zhi-wu Tong, Qian-hui Huang, Xia-hong Xie, Shi-yu Mao, Jian-hua Ding, Ming Lu, Ren-xiang Tan, Gang Hu
Parkinson’s disease (PD) is the second most common neurodegenerative disease, and its prevalence is increasing. Currently, no effective therapies for PD exist. Marine-derived natural compounds are considered important resources for the discovery of new drugs due to their distinctive structures and diverse activities. In this study, tetrahydroauroglaucin (TAG), a polyketide isolated from a marine sponge
-
Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-25 Jie Cheng, Ling Chen, Ya-ni Zheng, Juan Liu, Lei Zhang, Xiao-ming Zhang, Liang Huang, Qiong-lan Yuan
-
GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-21 Jia-hong Li, Ming Zhang, Zhao-di Zhang, Xiao-hua Pan, Li-long Pan, Jia Sun
-
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-22 Qi Su, Jing-jing Wang, Jia-yan Ren, Qing Wu, Kun Chen, Kai-hui Tu, Yu Zhang, Sze Wei Leong, Ammar Sarwar, Xu Han, Mi Zhang, Wei-feng Dai, Yan-min Zhang
-
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-21 Fei Wang, Yu Wang, Qing-yang Zhang, Ke-yu Hu, Ying-jie Song, Lin Yang, Fan Fei, Ceng-lin Xu, Sun-liang Cui, Ye-ping Ruan, Yi Wang, Zhong Chen
-
Vagus nerve stimulation as a promising neuroprotection for ischemic stroke via α7nAchR-dependent inactivation of microglial NLRP3 inflammasome Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-19 Xiao-mei Xia, Yu Duan, Yue-ping Wang, Rui-xue Han, Yin-feng Dong, Si-yuan Jiang, Yu Zheng, Chen Qiao, Lei Cao, Xiao Lu, Ming Lu
-
Notoginsenoside R1 promotes Lgr5+ stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-15 Zhi-lun Yu, Rui-yang Gao, Cheng Lv, Xiao-long Geng, Yi-jing Ren, Jing Zhang, Jun-yu Ren, Hao Wang, Fang-bin Ai, Zi-yi Wang, Bei-bei Zhang, Dong-hui Liu, Bei Yue, Zheng-tao Wang, Wei Dou
-
Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-15 Chang-yong Xu, Ji Jiang, Yue An, Peng-fei Ye, Cun-cun Zhang, Ning-ning Sun, Sai-nan Miao, Meng-qi Chai, Wen-min Liu, Mei Yang, Wei-hua Zhu, Jing-jing Yu, Man-man Yu, Wu-yi Sun, Huan Qiu, Shi-hao Zhang, Wei Wei
-
Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-12 Yi Liu, Si-jia Chen, Can Ai, Peng-xia Yu, Man Fang, Hui Wang
-
Clobetasol propionate, a Nrf-2 inhibitor, sensitizes human lung cancer cells to radiation-induced killing via mitochondrial ROS-dependent ferroptosis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-13 Archita Rai, Raghavendra S. Patwardhan, Sundarraj Jayakumar, Pradnya Pachpatil, Dhruv Das, Girish Ch. Panigrahi, Vikram Gota, Sejal Patwardhan, Santosh K. Sandur
-
zDHHC20-driven S-palmitoylation of CD80 is required for its costimulatory function Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-11 Bin Lu, Yi-yun Sun, Bo-ya Chen, Bo Yang, Qiao-jun He, Jun Li, Ji Cao
-
HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-11 Ya-juan Guo, Jing-jing Yao, Zhen-zhen Guo, Ming Ding, Kun-lin Zhang, Qing-hong Shen, Yu Li, Shao-fang Yu, Ting Wan, Fu-ping Xu, Ying Wang, Xiao-xiao Qi, Jin-jun Wu, Jian-xin Chen, Zhong-qiu Liu, Lin-lin Lu
-
Macrod1 suppresses diabetic cardiomyopathy via regulating PARP1-NAD+-SIRT3 pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-08 Yu-ting Liu, Hong-liang Qiu, Hong-xia Xia, Yi-zhou Feng, Jiang-yang Deng, Yuan Yuan, Da Ke, Heng Zhou, Yan Che, Qi-zhu Tang
-
A novel mouse model of familial combined hyperlipidemia and atherosclerosis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-08 Mei-jie Chen, Yi-tong Xu, Lu Sun, Zhi-hua Wang, Peter J. Little, Li Wang, Xun-de Xian, Jian-ping Weng, Suo-wen Xu
-
Intestinal epithelial Krüppel-like factor 4 alleviates endotoxemia and atherosclerosis through improving NF-κB/miR-34a-mediated intestinal permeability Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-04 He-zhong-rong Nie, Yi-wen Zhou, Xiao-hong Yu, Cong-guo Yin, Ling-fei Li, Hui-qin Hao, Tao Yuan, Yong Pan
-
Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-04 Yin-da Qiu, Qi Yan, Yi Wang, Yan-fei Ye, Yan Wang, Meng-ying Wang, Pei-pei Wang, Shu-yuan Zhang, Da-long Wang, Hao Yan, Jing Ruan, Yun-jie Zhao, Le-hao Huang, Namki Cho, Kun Wang, Xiao-hui Zheng, Zhi-guo Liu
-
α4 nicotinic receptors on GABAergic neurons mediate a cholinergic analgesic circuit in the substantia nigra pars reticulata Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-04 Yu Han, Jia-qi Zhang, Ya-wei Ji, Yi-wen Luan, Shu-yi Li, Hui-zhen Geng, Ying Ji, Cui Yin, Su Liu, Chun-yi Zhou, Cheng Xiao
-
Brigatinib, a newly discovered AXL inhibitor, suppresses AXL-mediated acquired resistance to osimertinib in EGFR-mutated non-small cell lung cancer Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-03-04 Rui Han, Cong-hua Lu, Chen Hu, Yuan-yao Dou, Jun Kang, Cai-yu Lin, Di Wu, Wei-ling Jiang, Guo-qing Yin, Yong He
-
PHPB ameliorates memory deficits and reduces oxidative injury in Alzheimer’s disease mouse model by activating Nrf2 signaling pathway Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-26 Nian-ying Shang, Long-jian Huang, Jia-qi Lan, Yu-ying Kang, Jing-shu Tang, Hong-yue Wang, Xin-nan Li, Zhuo Sun, Qiu-yu Chen, Meng-yao Liu, Zi-peng Wen, Xin-hong Feng, Lei Wu, Ying Peng
-
Proteomics analysis of histone deacetylase inhibitor-resistant solid tumors reveals resistant signatures and potential drug combinations Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-21 Bing-bing Hao, Ke Ma, Jun-yu Xu, Ru-feng Fan, Wen-si Zhao, Xing-long Jia, Lin-hui Zhai, SangKyu Lee, Dong Xie, Min-jia Tan
-
Inflammation-related molecular signatures involved in the anticancer activities of brigatinib as well as the prognosis of EML4-ALK lung adenocarcinoma patient Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-15 Fu-jing Ge, Xiao-yang Dai, Yao Qiu, Xiang-ning Liu, Chen-ming Zeng, Xiao-yuan Xu, Yi-dan Chen, Hong Zhu, Qiao-jun He, Ren-hua Gai, Sheng-lin Ma, Xue-qin Chen, Bo Yang
-
Quantitative systems pharmacology modeling of HER2-positive metastatic breast cancer for translational efficacy evaluation and combination assessment across therapeutic modalities Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-15 Ya-ting Zhou, Jia-hui Chu, Shu-han Zhao, Ge-li Li, Zi-yi Fu, Su-jie Zhang, Xue-hu Gao, Wen Ma, Kai Shen, Yuan Gao, Wei Li, Yong-mei Yin, Chen Zhao
-
Transforming growth factor-β receptors: versatile mechanisms of ligand activation Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-13 Zheng-Jie Chia, Ying-nan Cao, Peter J. Little, Danielle Kamato
-
Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-07 Ruo-song Chen, Jing Liu, Yu-jun Wang, Kuan Ning, Jing-gen Liu, Zhi-qiang Liu
-
Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1 Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-07 Han Zhang, Fei Xie, Xiao-ya Yuan, Xin-tong Dai, Yun-feng Tian, Ming-ming Sun, Si-qi Yu, Jia-you Cai, Bin Sun, Wei-cheng Zhang, Chang-liang Shan
-
GPCRs involved in metabolic diseases: pharmacotherapeutic development updates Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-02-07 Cheng Jin, Hui Chen, Li Xie, Yuan Zhou, Li-li Liu, Jian Wu
-
tRF3-IleAAT reduced extracellular matrix synthesis in diabetic kidney disease mice by targeting ZNF281 and inhibiting ferroptosis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-29 Yun-yang Qiao, Jia-ling Ji, Wei-ling Hou, Gao-ting Qu, Shan-wen Li, Xing-yue Li, Ran Jin, Yin-fang Li, Hui-min Shi, Ai-qing Zhang
-
Desloratadine alleviates ALS-like pathology in hSOD1G93A mice via targeting 5HTR2A on activated spinal astrocytes Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-29 Jian Lu, An-xu He, Zhuo-ying Jin, Meng Zhang, Zhong-xin Li, Fan Zhou, Lin Ma, Hong-ming Jin, Jia-ying Wang, Xu Shen
-
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-26 Yan-ni Zhao, Zhou-di Liu, Tao Yan, Ting-xin Xu, Tian-yang Jin, Yong-sheng Jiang, Wei Zuo, Kwang Youl Lee, Li-jiang Huang, Yi Wang
-
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-24 Chen Cheng, Chao Ren, Mu-zi Li, Yi-hui Liu, Ren-qi Yao, Yang Yu, Xuan Yu, Jian-li Wang, Li-xue Wang, Yu-chun Leng, Hui Zhang, Fei-fei Du, Ning Dong, Feng-qing Wang, Yao Wu, Fang Xu, Xiao-mei Zhu, Gui-ping Zhang, Kai Dong, Si Liu, Xiao-qing Yao, Chuan Li, Yong-ming Yao
-
Endothelial cell Orai1 is essential for endothelium-dependent contraction of mouse carotid arteries in normotensive and hypertensive mice Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-26 Xiao Li, Zhen-chuan Lei, Chun Yin Lo, Tsz Yau Jan, Chi Wai Lau, Xiao-qiang Yao
-
Mammalian integrated stress responses in stressed organelles and their functions Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-24 Hao-jun Lu, Nirmala Koju, Rui Sheng
-
Chronic vascular pathogenesis results in the reduced serum Metrnl levels in ischemic stroke patients Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-22 Zhu-wei Miao, Nuo Wang, Wen-jun Hu, Si-li Zheng, Dong-sheng Wang, Fu-qiang Chang, Zhi Wang, Jia-sheng Tian, Xiao-hui Dong, Tao Wu, Chao-yu Miao
-
The dual function of cGAS-STING signaling axis in liver diseases Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-17 Xiao-jiao-yang Li, Jiao-rong Qu, Yin-hao Zhang, Run-ping Liu
-
Mangiferin alleviates diabetic pulmonary fibrosis in mice via inhibiting endothelial-mesenchymal transition through AMPK/FoxO3/SIRT3 axis Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-15 Ting-lv Fu, Guo-rui Li, Dong-hang Li, Ru-yuan He, Bo-hao Liu, Rui Xiong, Chen-zhen Xu, Zi-long Lu, Cong-kuan Song, Hong-liang Qiu, Wen-jie Wang, Shi-shi Zou, Ke Yi, Ning Li, Qing Geng
-
Targeted inhibition of the HNF1A/SHH axis by triptolide overcomes paclitaxel resistance in non-small cell lung cancer Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-16 Ling-bing Li, Ling-xiao Yang, Lei Liu, Fan-rong Liu, Alex H. Li, Yi-lin Zhu, Hao Wen, Xia Xue, Zhong-xian Tian, Hong Sun, Pei-chao Li, Xiao-gang Zhao
-
CCDC92 promotes podocyte injury by regulating PA28α/ABCA1/cholesterol efflux axis in type 2 diabetic mice Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-16 Fu-wen Zuo, Zhi-yong Liu, Ming-wei Wang, Jun-yao Du, Peng-zhong Ding, Hao-ran Zhang, Wei Tang, Yu Sun, Xiao-jie Wang, Yan Zhang, Yu-sheng Xie, Ji-chao Wu, Min Liu, Zi-ying Wang, Fan Yi
-
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-15 Shi-chun Shen, Jie Xu, Cheng Cheng, Xin-jian Xiang, Bao-yu Hong, Meng Zhang, Chen Gong, Li-kun Ma
-
Corynoxine promotes TFEB/TFE3-mediated autophagy and alleviates Aβ pathology in Alzheimer’s disease models Acta Pharmacol. Sin. (IF 8.2) Pub Date : 2024-01-15 Xin-jie Guan, Zhi-qiang Deng, Jia Liu, Cheng-fu Su, Benjamin Chun-Kit Tong, Zhou Zhu, Sravan Gopalkrishnashetty Sreenivasmurthy, Yu-xuan Kan, Ke-jia Lu, Carol Pui-Kei Chu, Rong-biao Pi, King-ho Cheung, Ashok Iyaswamy, Ju-xian Song, Min Li