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Backflow reduction in local injection therapy with gelatin formulations Drug Deliv. (IF 6.0) Pub Date : 2024-03-22 Kazuki Kotani, Francois Marie Ngako Kadji, Yoshinobu Mandai, Yosuke Hiraoka
The local injection of therapeutic drugs, including cells, oncolytic viruses and nucleic acids, into different organs is an administrative route used to achieve high drug exposure at the site of ac...
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Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment Drug Deliv. (IF 6.0) Pub Date : 2024-02-29 Anna Szabó, Ignace De Decker, Sam Semey, Karel E.Y. Claes, Phillip Blondeel, Stan Monstrey, Jo Van Dorpe, Sandra Van Vlierberghe
Burn injuries can result in a significant inflammatory response, often leading to hypertrophic scarring (HTS). Local drug therapies e.g. corticoid injections are advised to treat HTS, although they...
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Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system Drug Deliv. (IF 6.0) Pub Date : 2024-02-16 MeeiChyn Goh, Meng Du, Wang Rui Peng, Phei Er Saw, Zhiyi Chen
Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challe...
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A mini-review on gene delivery technique using nanoparticles-mediated photoporation induced by nanosecond pulsed laser Drug Deliv. (IF 6.0) Pub Date : 2024-01-21 Xiaofan Du, Meng Zhao, Le Jiang, Lihui Pang, Jing Wang, Yi Lv, Cuiping Yao, Rongqian Wu
Nanosecond pulsed laser induced photoporation has gained increasing attention from scholars as an effective method for delivering the membrane-impermeable extracellular materials into living cells....
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Breaking boundaries: the advancements in transdermal delivery of antibiotics Drug Deliv. (IF 6.0) Pub Date : 2024-01-19 Ahlam Zaid Alkilani, Rania Hamed, Batool Musleh, Zaina Sharaire
Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in recent years that aimed to improve the efficacy and safety of these drugs. TDDS offer many advantages over...
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Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria Drug Deliv. (IF 6.0) Pub Date : 2024-01-05 Ellen K. G. Mhango, Benjamin R. Sveinbjornsson, Bergthora S. Snorradottir, Sveinbjorn Gizurarson
Lipophilic drugs require more advance formulation, especially if the intention is to make solutions or semisolid formulations. This also accounts for most antimalarial drugs. Although some of these...
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Biodegradable polymeric insulin microneedles – a design and materials perspective review Drug Deliv. (IF 6.0) Pub Date : 2023-12-26 Melbha Starlin Chellathurai, Syed Mahmood, Zarif Mohamed Sofian, Cheng Wan Hee, Ramkanth Sundarapandian, Haja Nazeer Ahamed, C. S. Kandasamy, Ayah R. Hilles, Najihah Mohd Hashim, Ashok Kumar Janakiraman
Microneedle (MN) delivery devices are more accepted by people than regular traditional needle injections (e.g. vaccination) due to their simplicity and adaptability. Thus, patients of chronic disea...
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Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective Drug Deliv. (IF 6.0) Pub Date : 2023-12-26 Shengnan Li, Fengmei Li, Yan Wang, Wenqun Li, Junyong Wu, Xiongbin Hu, Tiantian Tang, Xinyi Liu
Acute myocardial infarction, characterized by high morbidity and mortality, has now become a serious health hazard for human beings. Conventional surgical interventions to restore blood flow can ra...
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Advances in the use of local anesthetic extended-release systems in pain management Drug Deliv. (IF 6.0) Pub Date : 2023-12-21 Yulu Chen, Jingmei Xu, Ping Li, Liyang Shi, Sha Zhang, Qulian Guo, Yong Yang
Pain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management. The main limitation of traditional local an...
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Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance Drug Deliv. (IF 6.0) Pub Date : 2023-12-11 Sheetal S. Buddhadev, Kevinkumar C. Garala, Saisivam S, Mohamed Rahamathulla, Mohammed Muqtader Ahmed, Syeda Ayesha Farhana, Ismail Pasha
The primary objective of the research effort is to establish efficient solid self-nanoemulsifying drug delivery systems (S-SNEDDS) for benidipine (BD) through the systematic application of a qualit...
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The direct transfer approach for transcellular drug delivery Drug Deliv. (IF 6.0) Pub Date : 2023-11-30 Yi-Fan Wang, Ze-Fan Shen, Fang-yue Xiang, Heng Wang, Pu Zhang, Qi Zhang
A promising paradigm for drug administration that has garnered increasing attention in recent years is the direct transfer (DT) of nanoparticles for transcellular drug delivery. DT requires direct ...
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An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications Drug Deliv. (IF 6.0) Pub Date : 2023-12-01 Wenqing Liang, Chao Zhou, Songtao Jin, Lifeng Fu, Hengjian Zhang, Xiaogang Huang, Hengguo Long, Wenyi Ming, Jiayi Zhao
Nanotechnology has made significant progress in various fields, including medicine, in recent times. The application of nanotechnology in drug delivery has sparked a lot of research interest, espec...
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Lipidization as a tool toward peptide therapeutics Drug Deliv. (IF 6.0) Pub Date : 2023-11-27 Aneta Myšková, David Sýkora, Jaroslav Kuneš, Lenka Maletínská
Peptides, as potential therapeutics continue to gain importance in the search for active substances for the treatment of numerous human diseases, some of which are, to this day, incurable. As poten...
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Spray-dried nanocrystal-loaded polymer microparticles for long-term release local therapies: an opportunity for poorly soluble drugs Drug Deliv. (IF 6.0) Pub Date : 2023-11-22 Carlos Rodríguez-Nogales, Joke Meeus, Gaby Thonus, Sam Corveleyn, Eric Allémann, Olivier Jordan
Nano- and micro-technologies can salvage drugs with very low solubility that were doomed to pre-clinical and clinical failure. A unique design approach to develop drug nanocrystals (NCs) loaded in ...
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Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum Drug Deliv. (IF 6.0) Pub Date : 2023-11-21 Koyeli Girigoswami, Pragya Pallavi, Agnishwar Girigoswami
It is evident that site-specific systemic drug delivery can reduce side effects, systemic toxicity, and minimal dosage requirements predominantly by delivering drugs to particular pathological site...
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Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases Drug Deliv. (IF 6.0) Pub Date : 2023-09-13 Xinyu Wang, Ruru Bai
Abstract Magnetic Drug Targeting (MDT) is of particular interest to researchers because of its good loading efficiency, targeting accuracy, and versatile use in vivo. Cardiovascular Disease (CVD) is a global chronic disease with a high mortality rate, and the development of more precise and effective treatments is imminent. A growing number of studies have begun to explore the feasibility of MDT in
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Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model Drug Deliv. (IF 6.0) Pub Date : 2023-09-13 Robert J. Connor, Renee Clift, David W. Kang
Abstract Subcutaneous (SC) infusion of large volumes at rapid flow rates has historically been limited by the glycosaminoglycan hyaluronan (HA), which forms a barrier to bulk fluid flow in the SC space. Recombinant human hyaluronidase PH20 (rHuPH20) depolymerizes HA, temporarily eliminating this barrier to rapid SC delivery of large volume co-administered therapeutics. Using a miniature pig model,
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Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions Drug Deliv. (IF 6.0) Pub Date : 2023-09-05 Shimaa A. Elbanna, Heba M. K. Ebada, Ossama Y. Abdallah, Marwa M. Essawy, Hend M. Abdelhamid, Hebatallah S. Barakat
Abstract Oral cancer is one of the leading causes of death worldwide. Oral precancerous lesions (OPL) are the precursors of oral cancer, with varying degrees of progression. Tetrahydrocurcumin (THC) is a major metabolite of curcumin with superior anticancer properties against various types of cancer. However, THC’s clinical outcome is limited by its poor aqueous solubility. Herein, we developed novel
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Kartogenin delivery systems for biomedical therapeutics and regenerative medicine Drug Deliv. (IF 6.0) Pub Date : 2023-09-04 Peixing Chen, Xiaoling Liao
Abstract Kartogenin, a small and heterocyclic molecule, has emerged as a promising therapeutic agent for incorporation into biomaterials, owing to its unique physicochemical and biological properties. It holds potential for the regeneration of cartilage-related tissues in various common conditions and injuries. Achieving sustained release of kartogenin through appropriate formulation and efficient
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Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model Drug Deliv. (IF 6.0) Pub Date : 2023-08-30 Kainat Nousheen, Fakhar Ud Din, Humzah Jamshaid, Rabia Afza, Saif Ullah Khan, Maimoona Malik, Zakir Ali, Sibgha Batool, Alam Zeb, Abid Mehmood Yousaf, Ali H. Almari, Saud Alqahtani, Salman Khan, Gul Majid Khan
Abstract Herein we designed, optimized, and characterized the Metformin Hydrochloride Transethosomes (MTF-TES) and incorporate them into Chitosan gel to develop Metformin Hydrochloride loaded Transethosomal gel (MTF-TES gel) that provides a sustained release, improved transdermal flux and improved antidiabetic response of MTF. Design Expert® software (Ver. 12, Stat-Ease, USA) was applied for the statistical
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Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules Drug Deliv. (IF 6.0) Pub Date : 2023-08-09 Ashif Iqubal, Abul Kalam Najmi, Shadab Md, Huda Mohammed Alkreathy, Javed Ali, Mansoor Ali Syed, Syed Ehtaishamul Haque
Abstract Cyclophosphamide (CP) is one of the most extensively used antineoplastic drug, but the nephrotoxicity caused by this drug is a major limiting factor for its use. Nerolidol (NERO) is a natural bioactive compound with diverse pharmacological actions. In Vitro and in vivo study was performed using HK-2 renal cells and Swiss Albino mice. Cell lines and animals were treated with NERO 25 and 50 µM
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Topically applied pH-responsive nanogels for alkyl radical-based therapy against psoriasiform hyperplasia Drug Deliv. (IF 6.0) Pub Date : 2023-08-10 G.R. Nirmal, Chia-Chih Liao, Zih-Chan Lin, Abdullah Alshetaili, Erica Hwang, Shih-Chun Yang, Jia-You Fang
Abstract Phototherapy is a conventional antipsoriatic approach based on oxygen-relevant generation of oxidative stress to inhibit keratinocyte hyperproliferation. However, this therapy can be restricted due to local hypoxia in psoriatic lesions. The generation of alkyl radicals is oxygen-independent and suppresses hyperproliferation. Herein, we established alkyl radical-based therapy to treat psoriatic
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Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis Drug Deliv. (IF 6.0) Pub Date : 2023-08-06 Xiao-Xiao Fu, Han Qu, Jing Wang, Hua-Ying Cai, Hong Jiang, Hao-Hao Chen, Shu Han
Abstract Gradual loss of neuronal structure and function due to impaired blood–brain barrier (BBB) and neuroinflammation are important factors in multiple sclerosis (MS) progression. Our previous studies demonstrated that the C16 peptide and angiopoietin 1 (Ang-1) compound (C + A) could modulate inflammation and vascular protection in many models of MS. In this study, nanotechnology and a novel nanovector
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Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro, in silico, and in-vivo study Drug Deliv. (IF 6.0) Pub Date : 2023-08-03 Sammar Fathy Elhabal, Mohamed A El-Nabarawi, Nashwa Abdelaal, Mohamed Fathi Mohamed Elrefai, Shrouk A. Ghaffar, Mohamed Mansour Khalifa, Passant M. Mohie, Dania S. Waggas, Ahmed Mohsen Elsaid Hamdan, Samar Zuhair Alshawwa, Essa M. Saied, Nahla A. Elzohairy, Tayseer Elnawawy, Rania A. Gad, Nehal Elfar, Hanaa Mohammed, Mohammad Ahmad Khasawneh
Abstract Canagliflozin (CFZ) is a sodium-glucose cotransporter-2 inhibitor (SGLT2) that lowers albuminuria in type-2 diabetic patients, cardiovascular, kidney, and liver disease. CFZ is classified as class IV in the Biopharmaceutical Classification System (BCS) and is characterized by low permeability, solubility, and bioavailability, most likely attributed to hepatic first-pass metabolism. Nanocrystal-based
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Sustained delivery of triamcinolone acetonide from a thermosensitive microemulsion gel system for the treatment of sensorineural hearing loss Drug Deliv. (IF 6.0) Pub Date : 2023-08-03 Thu Nhan Nguyen, So-Yeol Yoo, Warisraporn Tangchang, Jae-Young Lee, Hwa-Young Son, Jeong-Sook Park
Abstract Intratympanic administration for the delivery of steroids has been extensively studied but limited because of low permeability of the drug through the row window membrane. Here, to effectively deliver poorly soluble triamcinolone acetonide (TA), microemulsions (ME) were prepared from Capmul MCM (oil), Cremophor RH40 (surfactant), and tetraglycol (cosurfactant) based on solubility studies,
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Sustained release gel (polymer-free) of itraconazole-loaded microemulsion for oral candidiasis treatment: time-kill kinetics and cellular uptake Drug Deliv. (IF 6.0) Pub Date : 2023-07-14 Sukannika Tubtimsri, Yotsanan Weerapol
Abstract Itraconazole (ICZ) was prepared in a self-microemulsifying (SM) gel. This gel was intended for use in the oral mucosa, where low volume and flow of saliva result in limited solubility and absorption of drugs that are poorly water-soluble. The drug-loaded gel formulation (ICZ-SM) was selected as a clear solution in the ternary phase diagram to improve the solubility of ICZ. Seven ratios (S1–S7)
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Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system Drug Deliv. (IF 6.0) Pub Date : 2023-07-12 Jiaqi Weng, Gensuo Zheng, Jiaoli Wen, Jing Yang, Qingliang Yang, Xi Zheng, Qinying Yan
Abstract Conventional treatments for tumors were frequently accompanied by drawbacks and side effects. It might be useful to use the revolutionary microneedle technology which combines photothermal therapy with tumor immunotherapy. In this study, we created a microneedle drug delivery system with mercapto-modified gold nanorods and immune checkpoint blocker anti-PD-1 polypeptide. With good mechanical
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Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability Drug Deliv. (IF 6.0) Pub Date : 2023-07-11 Ce Yi, Fei Xie, Xin Xu, Dian Xiao, Xinbo Zhou, Maosheng Cheng
Abstract Aiming to address the insufficient endocytosis ability of traditional albumin drug conjugates, this paper reports elegant guanidine modification to improve efficacy for the first time. A series of modified albumin drug conjugates were designed and synthesized with different structures, including guanidine (GA), biguanides (BGA) and phenyl (BA), and different quantities of modifications. Then
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A click chemistry-based, free radical-initiated delivery system for the capture and release of payloads Drug Deliv. (IF 6.0) Pub Date : 2023-07-11 Emily T. DiMartini, Kelly Kyker-Snowman, David I. Shreiber
Abstract Click chemistries are efficient and selective reactions that have been leveraged for multi-stage drug delivery. A multi-stage system allows independent delivery of targeting molecules and drug payloads, but targeting first-phase materials specifically to disease sites remains a challenge. Stimuli-responsive systems are an emerging strategy where common pathophysiological triggers are used
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Triptorelin nanoparticle-loaded microneedles for use in assisted reproductive technology Drug Deliv. (IF 6.0) Pub Date : 2023-06-30 Xiaoyan Lu, Yiying Sun, Meishan Han, Daoyuan Chen, Xiaoyan He, Siqi Wang, Kaoxiang Sun
Abstract Triptorelin is a first-line drug for assisted reproductive technology (ART), but the low bioavailability and frequent subcutaneous injection of triptorelin impair the quality of life of women preparing to become pregnant. We report silk fibroin (SF)-based microneedles (MNs) for transdermal delivery of triptorelin-loaded nanoparticles (NPs) to improve bioavailability and achieve safe and efficacious
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Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors Drug Deliv. (IF 6.0) Pub Date : 2023-06-21 Ai Wei Lim, Nicholas J. Talley, Marjorie M. Walker, Gert Storm, Susan Hua
Abstract Diseases affecting the esophagus are common. However, targeted drug delivery to the esophagus is challenging due to the anatomy and physiology of this organ. Current pharmacological treatment for esophageal diseases predominantly relies on the off-label use of drugs in various dosage forms, including those for systemic drug delivery (e.g. oral tablets, sublingual tablets, and injections) and
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Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution Drug Deliv. (IF 6.0) Pub Date : 2023-06-21 T. J. Snoeijink, T. G. Vlogman, J. Roosen, E. Groot Jebbink, K. Jain, J.F.W. Nijsen
Abstract [Purpose] Transarterial radioembolization (TARE) is an established treatment modality for patients with unresectable liver cancer. However, a better understanding of treatment parameters that influence microsphere distribution could further improve the therapy. This systematic review examines and summarizes the available evidence on intraprocedural parameters that influence the microsphere
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PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA Drug Deliv. (IF 6.0) Pub Date : 2023-06-19 Yingying Xu, Yijing Zheng, Xuqiu Ding, Chengyan Wang, Bin Hua, Shilian Hong, Xiaoman Huang, Jiali Lin, Peng Zhang, Wei Chen
Abstract Inhalable messenger RNA (mRNA) has demonstrated great potential in therapy and vaccine development to confront various lung diseases. However, few gene vectors could overcome the airway mucus and intracellular barriers for successful pulmonary mRNA delivery. Apart from the low pulmonary gene delivery efficiency, nonnegligible toxicity is another common problem that impedes the clinical application
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Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers Drug Deliv. (IF 6.0) Pub Date : 2023-06-15 Mohamed Mashal, Noha Attia, Santiago Grijalvo, Ramón Eritja, Gustavo Puras, José Luis Pedraz
Abstract This study aims to explore the stability of lipo-polymeric niosomes/niosome-based pCMS-EGFP complexes under different storage temperatures (25 °C, 4 °C, and −20 °C). To date, the question of nucleic acid-complex stability is one of the most vital issues in gene delivery applications. The need for stable vaccines during the COVID-19 pandemic has merely highlighted it. In the case of niosomes
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A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors Drug Deliv. (IF 6.0) Pub Date : 2023-06-14 Farshad Moradi Kashkooli, Mohammad Souri, Jahangir (Jahan) Tavakkoli, Michael C. Kolios
Abstract Focused Ultrasound (FUS)-triggered nano-sized drug delivery, as a smart stimuli-responsive system for treating solid tumors, is computationally investigated to enhance localized delivery of drug and treatment efficacy. Integration of thermosensitive liposome (TSL), as a doxorubicin (DOX)-loaded nanocarrier, and FUS, provides a promising drug delivery system. A fully coupled partial differential
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Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity Drug Deliv. (IF 6.0) Pub Date : 2023-06-12 Lin Wang, Huanchun Xing, Shuai Guo, Wenbin Cao, Zinan Zhang, Lijuan Huang, Sui Xin, Yuan Luo, Yongan Wang, Jun Yang
Abstract Messenger RNA (mRNA) has become one of the most potential drugs in recent years. However, efficient and safe delivery of fragile and easily degradable mRNA is a major challenge. Appropriate delivery system (DS) determines the final effect of mRNA. Cationic lipids play a crucial and decisive role in the entire DS, but also cause huge biosafety problems due to the high toxicity. In this study
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M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver Drug Deliv. (IF 6.0) Pub Date : 2023-06-10 Xiaochuan Tan, Yumei Hao, Nai Ma, Yige Yang, Wenzhen Jin, Ya Meng, Chuchu Zhou, Wensheng Zheng, Yujia Zhang
Abstract Liver fibrosis is a key pathological process shared by the progression of various chronic liver diseases. Treatment of liver fibrosis can effectively block the occurrence and development of hepatic cirrhosis or even carcinoma. Currently, there is no effective drug delivery vehicle for curing liver fibrosis. In this study, we designed matrine (MT)-loaded mannose 6-phosphate (M6P) modified human
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Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives Drug Deliv. (IF 6.0) Pub Date : 2023-06-08 Min Chen, Huanrong Lan, Ketao Jin, Yun Chen
Abstract The pharmacological approach to treating gastrointestinal diseases is suffering from various challenges. Among such gastrointestinal diseases, ulcerative colitis manifests inflammation at the colon site specifically. Patients suffering from ulcerative colitis notably exhibit thin mucus layers that offer increased permeability for the attacking pathogens. In the majority of ulcerative colitis
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Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy Drug Deliv. (IF 6.0) Pub Date : 2023-06-07 Wen Zhang, Peng Zhang, Xiaopeng Xu, Minghui Li, Shasha Wang, Hongjie Mu, Kaoxiang Sun
Abstract Doxorubicin (DOX) is a commonly studied chemotherapeutic agent for the treatment of solid tumors, but the severe side effects limit its clinical application. It is shown that DOX-metal chelate has lower in vitro cytotoxicity compared with DOX, as the anthracyclines of DOX can form coordinative interaction with transition metal ions. In addition, the transition metal ions could catalyze the
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Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems Drug Deliv. (IF 6.0) Pub Date : 2023-06-05 Rebeca Martinez-Borrajo, Patricia Diaz-Rodriguez, Mariana Landin
Abstract Polymeric microparticles are widely used as drug delivery platforms either alone or embedded in more complex structures for regenerative medicine. Emulsion-solvent evaporation is the most extensively used technique for microparticles preparation. Despite the apparent simplicity of this method, there is no general procedure for producing microparticles of predictable characteristics (particle
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Therapeutic applications of contact lens-based drug delivery systems in ophthalmic diseases Drug Deliv. (IF 6.0) Pub Date : 2023-06-02 Lianghui Zhao, Jike Song, Yongle Du, Cong Ren, Bin Guo, Hongsheng Bi
Abstract Traditional ophthalmic drugs, such as eye drops, gels and ointments, are accompanied by many problems, including low bioavailability and potential drug side effects. Innovative ophthalmic drug delivery systems have been proposed to overcome the limitations associated with traditional formulations. Recently, contact lens-based drug delivery systems have gained popularity owing to their advantages
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Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release Drug Deliv. (IF 6.0) Pub Date : 2023-06-02 Meiyao Wang, Huazhen Xu, Tongfei Li, Ke Li, Quan Zhang, Siyi Chen, Li Zhao, Jincao Chen, Xiao Chen
Abstract Sonodynamic therapy (SDT) has aroused great interest for its potential in the treatment of glioblastoma (GBM). SDT relies on tumor-selective accumulation of a sonosensitizer that is activated by ultrasound irradiation (UI) to generate cytotoxic actions. The efficacy of GBM-SDT depends on sufficient sonosensitizer buildup in the tumor, which is, however, seriously hampered by the anatomical
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Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment Drug Deliv. (IF 6.0) Pub Date : 2023-05-16 Hui Jiang, Zhuping Xu
Abstract Ocular posterior segment diseases such as uveitis, X-linked juvenile retinoschisis, or age-related macular degeneration usually result in progressive and irreversible vision loss. Although intravitreal injection is the main way to deliver drugs to the posterior eye, it still has shortcomings as an invasive operation. Nanocontrolled drug delivery technology is a promising option to avoid frequent
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Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice Drug Deliv. (IF 6.0) Pub Date : 2023-05-03 Xiao Wang, Li Fu, Weijian Cheng, Jiamei Chen, Huan Zhang, Huanjun Zhu, Chen Zhang, Chaomei Fu, Yichen Hu, Jinming Zhang
Abstract How to achieve stable co-delivery of multiple phytochemicals is a common problem. This study focuses on the development, optimization and characterization of Huanglian-HouPo extract nanoemulsion (HLHPEN), with multiple components co-delivery, to enhance the anti-ulcerative colitis (UC) effects. The formulation of HLHPEN was optimized by pseudo-ternary phase diagram combined with Box-Behnken
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In vitro comparative study of multimodal imaging nano-assembled microspheres with two clinical drug-eluting beads loaded with doxorubicin Drug Deliv. (IF 6.0) Pub Date : 2023-04-20 Yiwei He, Tiancheng Xu, Tingting Ding, Yuanchuan Gong, Hui Zeng, Zihan Xi, Yuanxin Ye, Ziyang Song, Ting Pan, Zhewei Zhang, Qian Ma, Lihua Li, Yuqing Zhang, Guoliang Shao
Abstract DC Beads and CalliSpheres are commonly used microspheres in clinical transcatheter arterial chemoembolization, but these microspheres cannot be visualized by themselves. Therefore, in our previous study, we developed multimodal imaging nano-assembled microspheres (NAMs), which are visualized under CT/MR and the location of embolic microspheres can be determined during postoperative review
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Extravasation of biodegradable microspheres in the rat brain Drug Deliv. (IF 6.0) Pub Date : 2023-03-30 Anne-Eva van der Wijk, Theodosia Georgakopoulou, Rob Steendam, Johan Zuidema, Peter L. Hordijk, Erik N.T.P. Bakker, Ed van Bavel
Abstract Drug development for neurological diseases is greatly impeded by the presence of the blood-brain barrier (BBB). We and others previously reported on extravasation of micrometer-sized particles from the cerebral microcirculation – across the BBB – into the brain tissue over the course of several weeks. This mechanism could potentially be used for sustained parenchymal drug delivery after extravasation
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Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives Drug Deliv. (IF 6.0) Pub Date : 2023-03-25 Yuri Sugimoto, Tadaharu Suga, Mizuki Umino, Asako Yamayoshi, Hidefumi Mukai, Shigeru Kawakami
Abstract Functionalized drug delivery systems have been investigated to improve the targetability and intracellular translocation of therapeutic drugs. We developed high functionality and quality lipids that met unique requirements, focusing on the quality of functional lipids for the preparation of targeted nanoparticles using microfluidic devices. While searching for a lipid with high solubility
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Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management Drug Deliv. (IF 6.0) Pub Date : 2023-03-17 Haocheng Zhou, Dingquan Zou, Bo Hong, Rong Hu, Tongbiao Yang, Xinning Li, Xin Li, Junjiao Hu, Ruixuan Wang, Yaping Wang
Abstract Gadolinium-based MR cisternography has been mainly applied in clinical evaluation of cerebrospinal fluid leaking, that is conducted by intrathecal administration of contrast media. Recently, we have reported one novel technique of intrathecal targeted drug delivery with prepontine cisternal routine to treat orofacial cancer pain. The aim of this study was to examine the distribution pattern
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Merging konjac glucomannan with other copolymeric hydrogels as a cutting-edge liquid raft system for dual delivery of etoricoxib and famotidine Drug Deliv. (IF 6.0) Pub Date : 2023-03-17 Nabil A. Shoman, Marwa Saady, Mahmoud Teaima, Rehab Abdelmonem, Mohamed A. El-Nabarawi, Sammar Fathy Elhabal
Abstract This study aimed to formulate and evaluate a floating raft system for the co-delivery of etoricoxib (ETO) and famotidine (FAM) using a combination of glucomannan with natural/semi-synthetic polysaccharides. Formulation variables affect gelation lag time (GLT), floating lag time (FLT), and release percentage of drugs after 1–8 h, Stability, and viscosity parameters were evaluated. In vivo X-ray
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PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide Drug Deliv. (IF 6.0) Pub Date : 2023-03-14 Saeed A. S. Al-Zuhairy, Mahmoud H. Teaima, Nabil A. Shoman, Mohamed Elasaly, Mohamed A. El-Nabarawi, Hossam S. El-Sawy
Abstract A PEGylated Tween 80–functionalized chitosan–lipidic (PEG-T-Chito-Lip) nano-vesicular hybrid was developed for intranasal administration as an alternative delivery route to help improve the poor oral bioavailability of BCS class-III model/antiemetic (metoclopramide hydrochloride; MTC). The influence of varying levels of chitosan, cholesterol, PEG 600, and Tween 80 on the stability/release
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Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity Drug Deliv. (IF 6.0) Pub Date : 2023-03-15 Tianyu Zhang, Nuannuan Li, Ru Wang, Yiying Sun, Xiaoyan He, Xiaoyan Lu, Liuxiang Chu, Kaoxiang Sun
Abstract Doxorubicin (DOX), a commonly used anti-cancer drug, is limited by its cardiotoxicity and multidrug resistance (MDR) of tumor cells. Epigallocatechin gallate (EGCG), a natural antioxidant component, can effectively reduce the cardiotoxicity of DOX. Meanwhile, EGCG can inhibit the expression of P-glycoprotein (P-gp) and reverse the MDR of tumor cells. In this study, DOX is connected with low
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Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy Drug Deliv. (IF 6.0) Pub Date : 2023-03-14 Yaqin Tu, Wei Zhang, Guorun Fan, Chenming Zou, Jie Zhang, Nan Wu, Jiahui Ding, Wen Qing Zou, Hongjun Xiao, Songwei Tan
Abstract High intracellular reactive oxygen species (ROS) level is characteristic of cancer cells and could act as a target for the efficient targeted drug delivery for cancer treatment. Consequently, biomaterials that react to excessive levels of ROS are essential for biomedical applications. In this study, a novel ROS-responsive polymer based on D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS)
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Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors Drug Deliv. (IF 6.0) Pub Date : 2023-03-09 Mohammad Souri, Mohammad Kiani Shahvandi, Mohsen Chiani, Farshad Moradi Kashkooli, Ali Farhangi, Mohammad Reza Mehrabi, Arman Rahmim, Van M. Savage, M. Soltani
Abstract Nano-based drug delivery systems hold significant promise for cancer therapies. Presently, the poor accumulation of drug-carrying nanoparticles in tumors has limited their success. In this study, based on a combination of the paradigms of intravascular and extravascular drug release, an efficient nanosized drug delivery system with programmable size changes is introduced. Drug-loaded smaller
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Advance in placenta drug delivery: concern for placenta-originated disease therapy Drug Deliv. (IF 6.0) Pub Date : 2023-03-08 Miao Tang, Xiao Zhang, Weidong Fei, Yu Xin, Meng Zhang, Yao Yao, Yunchun Zhao, Caihong Zheng, Dongli Sun
Abstract In the therapy of placenta-originated diseases during pregnancy, the main challenges are fetal exposure to drugs, which can pass through the placenta and cause safety concerns for fetal development. The design of placenta-resident drug delivery system is an advantageous method to minimize fetal exposure as well as reduce adverse maternal off-target effects. By utilizing the placenta as a biological
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Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques Drug Deliv. (IF 6.0) Pub Date : 2023-03-06 Jae Geun Song, Kshitis Chandra Baral, Gyu-Lin Kim, Ji-Won Park, Soo-Hwa Seo, Da-Hyun Kim, Dong Hoon Jung, Nonye Linda Ifekpolugo, Hyo-Kyung Han
Abstract Pharmaceutical application of therapeutic proteins has been continuously expanded for the treatment of various diseases. Efficient and reliable bioanalytical methods are essential to expedite the identification and successful clinical development of therapeutic proteins. In particular, selective quantitative assays in a high-throughput format are critical for the pharmacokinetic and pharmacodynamic
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Design and evaluation of in situ gel eye drops containing nanoparticles of Gemifloxacin Mesylate Drug Deliv. (IF 6.0) Pub Date : 2023-03-06 Vishwa J. Kalaria, S. Saisivam, Anas Alshishani, Jameel S. Aljariri Alhesan, Sumit Chakraborty, Mohamed Rahamathulla
Abstract Traditional eye drops used for topically administering drugs have poor ocular bioavailability due to the biological barriers of the eye. There is an interest to design and develop novel drug delivery systems that would extend the precorneal residence time, reduce the frequency of administration and decrease dose-related toxicity. This study aimed to prepare Nanoparticles of Gemifloxacin Mesylate
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A detailed insight of the tumor targeting using nanocarrier drug delivery system Drug Deliv. (IF 6.0) Pub Date : 2023-03-03 Sibgha Batool, Saba Sohail, Fakhar ud Din, Ali H. Alamri, Ahmad S. Alqahtani, Mohammad A. Alshahrani, Mohammed A. Alshehri, Han Gon Choi
Abstract Human struggle against the deadly disease conditions is continued since ages. The contribution of science and technology in fighting against these diseases cannot be ignored exclusively due to the invention of novel procedure and products, extending their size ranges from micro to nano. Recently nanotechnology has been gaining more consideration for its ability to diagnose and treat different
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Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice Drug Deliv. (IF 6.0) Pub Date : 2023-03-02 Shiyun Xian, Jiabin Zhu, Yuchen Wang, Haihan Song, Hangxiang Wang
Abstract Inflammatory bowel disease (IBD) is one of the most common intestinal disorders, with increasing global incidence and prevalence. Numerous therapeutic drugs are available but require intravenous administration and are associated with high toxicity and insufficient patient compliance. Here, an oral liposome that entraps the activatable corticosteroid anti-inflammatory budesonide was developed
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Physicochemical properties and micro-interaction between micro-nanoparticles and anterior corneal multilayer biological interface film for improving drug delivery efficacy: the transformation of tear film turnover mode Drug Deliv. (IF 6.0) Pub Date : 2023-03-03 Huamei Li, Fuda Dai, Hanyu Liu, Qi Tao, Jie Hu, Yangrong Zhang, Zhenping Xiao, Ilva D. Rupenthal, Huihui Li, Fan Yang, Wei Li, Huaqing Lin, Dongzhi Hou
Abstract Recently, various novel drug delivery systems have been developed to overcome ocular barriers in order to improve drug efficacy. We have previously reported that montmorillonite (MT) microspheres (MPs) and solid lipid nanoparticles (SLNs) loaded with the anti-glaucoma drug betaxolol hydrochloride (BHC) exhibited sustained drug release and thus intraocular pressure (IOP) lowering effects. Here
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Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma Drug Deliv. (IF 6.0) Pub Date : 2023-03-01 Qian Ju, Rong Huang, Ruimin Hu, Junjie Fan, Dinglin Zhang, Jun Ding, Rong Li
Abstract Osteosarcoma is the most common malignant tumor in the skeletal system with high mortality. Phytic acid (PA) is a natural compound extracted from plant seeds, which shows certain antitumor activity and good bone targeting ability. To develop a novel theranostics for magnetic resonance imaging (MRI) and targeting therapy of osteosarcoma, we employed PA to modify manganese dioxide nanoparticles