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β2* nAChR sensitivity modulates acquisition of cocaine self-administration in male rats Neuropharmacology (IF 4.7) Pub Date : 2024-03-18 Noah B. Walker, Brenton R. Tucker, Leanne N. Thomas, Andrew E. Tapp, Anna I. Neel, Rong Chen, Sara R. Jones, Ryan M. Drenan
Signaling through nicotinic acetylcholine receptors (nAChRs) plays a role in cocaine reward and reinforcement, suggesting that the cholinergic system could be manipulated with therapeutics to modulate aspects of cocaine use disorder (CUD). We examined the interaction between nAChRs and cocaine reinforcement by expressing a hypersensitive β2 nAChR subunit (β2Leu9′Ser) in the ventral tegmental area of
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Resveratrol evokes neuroprotective effects and improves foot stance following kainate-induced excitotoxic damage to the mouse spinal cord Neuropharmacology (IF 4.7) Pub Date : 2024-03-16 Benjamín Zylberberg, Martina Poodts, Julieta Roncoroni, M. Florencia Coronel, Graciela L. Mazzone
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Neuro-modulatory impact of felodipine against experimentally-induced Parkinson's disease: Possible contribution of PINK1-Parkin mitophagy pathway Neuropharmacology (IF 4.7) Pub Date : 2024-03-15 Hadeer O. Abou-Hany, Mohamed El-Sherbiny, Sally Elshaer, Eman Said, Tarek Moustafa
Parkinson's disease (PD) is a prevalent neurodegenerative disorder, characterized by motor and psychological dysfunction. Palliative treatment and dopamine replenishment therapy are the only available therapeutic options. Calcium channel blockers (CCBs) have been reported to protect against several neurodegenerative disorders. The current study was designed to evaluate the neuroprotective impact of
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PGC-1α in the hippocampus mediates depressive-like and stress-coping behaviours and regulates excitatory synapses in the dentate gyrus in mice Neuropharmacology (IF 4.7) Pub Date : 2024-03-15 Yuhui Deng, Xin Liang, Yue Li, Lin Jiang, Jin Wang, Jing Tang, Jing Li, Yuhan Xie, Kai Xiao, Peilin Zhu, Yijing Guo, Yanmin Luo, Yong Tang
Decreased hippocampal synaptic plasticity is an important pathological change in stress-related mood disorders, including major depressive disorder. However, the underlying mechanism is unclear. PGC-1α, a transcriptional coactivator, is a key factor in synaptic plasticity. We investigated the relationships between changes in hippocampal PGC-1α expression and depressive-like and stress-coping behaviours
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Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9 Neuropharmacology (IF 4.7) Pub Date : 2024-03-14 Jiang Li, Shuaiying Jia, Yuehan Song, Wenmei Xu, Jingyan Lin
The glymphatic system plays a crucial role in maintaining optimal central nervous system (CNS) function by facilitating the removal of metabolic wastes. Aquaporin-4 (AQP4) protein, predominantly located on astrocyte end-feet, is a key pathway for metabolic waste excretion. β-Dystroglycan (β-DG) can anchor AQP4 protein to the end-feet membrane of astrocytes and can be cleaved by matrix metalloproteinase
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Roles of mechanosensitive ion channel PIEZO1 in the pathogenesis of brain injury after experimental intracerebral hemorrhage Neuropharmacology (IF 4.7) Pub Date : 2024-03-13 Min Qi, Ran Liu, Fan Zhang, Zhipeng Yao, Meng-liang Zhou, Xiaochun Jiang, Shizhang Ling
Secondary brain injury after intracerebral hemorrhage (ICH) is the main cause of poor prognosis in ICH patients, but the underlying mechanisms remain less known. The involvement of Piezo1 in brain injury after ICH was studied in a mouse model of ICH. ICH was established by injecting autologous arterial blood into the basal ganglia in mice. After vehicle, Piezo1 blocker, GsMTx4, Piezo1 activator, Yoda-1
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Novel pharmacological targets for GABAergic dysfunction in ADHD Neuropharmacology (IF 4.7) Pub Date : 2024-03-08 Anthony S. Ferranti, Deborah J. Luessen, Colleen M. Niswender
Attention deficit/hyperactivity disorder (ADHD) is a neurodevelopment disorder that affects approximately 5% of the population. The disorder is characterized by impulsivity, hyperactivity, and deficits in attention and cognition, although symptoms vary across patients due to the heterogenous and polygenic nature of the disorder. Stimulant medications are the standard of care treatment for ADHD patients
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Retraction Notice to “Ibuprofen or piroxicam protects nigral neurons and delays the development of l-dopa induced dyskinesia in rats with experimental Parkinsonism: Influence on angiogenesis” [Neuropharmacology, 107 (2016) 432 – 450] Neuropharmacology (IF 4.7) Pub Date : 2024-03-05 Asmaa M. Teema, Sawsan A. Zaitone, Yasser M. Moustafa
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Quantitative T2 mapping-based longitudinal assessment of brain injury and therapeutic rescue in the rat following acute organophosphate intoxication Neuropharmacology (IF 4.7) Pub Date : 2024-03-02 Alita Jesal D. Almeida, Brad A. Hobson, Naomi Saito, Donald A. Bruun, Valerie A. Porter, Danielle J. Harvey, Joel R. Garbow, Abhijit J. Chaudhari, Pamela J. Lein
Acute intoxication with organophosphate (OP) cholinesterase inhibitors poses a significant public health risk. While currently approved medical countermeasures can improve survival rates, they often fail to prevent chronic neurological damage. Therefore, there is need to develop effective therapies and quantitative metrics for assessing OP-induced brain injury and its rescue by these therapies. In
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The mast cells - Cytokines axis in Autism Spectrum Disorder Neuropharmacology (IF 4.7) Pub Date : 2024-03-01 Eleonora Kovacheva, Maria Gevezova, Michael Maes, Victoria Sarafian
Autism Spectrum Disorder (ASD) is a neurodevelopmental disturbance, diagnosed in early childhood. It is associated with varying degrees of dysfunctional communication and social skills, repetitive and stereotypic behaviors. Regardless of the constant increase in the number of diagnosed patients, there are still no established treatment schemes in global practice. Many children with ASD have allergic
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Retigabine and gabapentin restore channel function and neuronal firing in a cellular model of an epilepsy-associated dominant-negative KCNQ5 variant Neuropharmacology (IF 4.7) Pub Date : 2024-02-29 Johanna Krüger, Holger Lerche
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Exploring the therapeutic potential of cannabidiol for sleep deprivation-induced hyperalgesia Neuropharmacology (IF 4.7) Pub Date : 2024-02-28 Kangsheng Zhu, Siruan Chen, Xia Qin, Wanjun Bai, Jie Hao, Xiaolei Xu, Han Guo, Hui Bai, Zuxiao Yang, Sheng Wang, Zongmao Zhao, Tengfei Ji, Dezhi Kong, Wei Zhang
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Opioid modulation of prefrontal cortex cells and circuits Neuropharmacology (IF 4.7) Pub Date : 2024-02-27 Rebecca H. Cole, Khaled Moussawi, Max E. Joffe
Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive and motivated behaviors. A rich network of endogenous opioid peptides and receptors spans multiple PFC cell types and circuits, and this extensive opioid system has emerged as a key substrate underlying reward, motivation, affective behaviors, and adaptations to stress. Here, we review the current evidence for
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Using artificial intelligence to identify drugs for repurposing to treat l-DOPA-induced dyskinesia Neuropharmacology (IF 4.7) Pub Date : 2024-02-25 Tom H. Johnston, Alix M.B. Lacoste, Paula Ravenscroft, Jin Su, Sahar Tamadon, Mahtab Seifi, Anthony E. Lang, Susan H. Fox, Jonathan M. Brotchie, Naomi P. Visanji
Repurposing regulatory agency-approved molecules, with proven safety in humans, is an attractive option for developing new treatments for disease. We identified and assessed the efficacy of 3 drugs predicted by an screen as having the potential to treat -DOPA-induced dyskinesia (LID) in Parkinson's disease.
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Dopamine-loaded chitosan-coated solid lipid nanoparticles as a promise nanocarriers to the CNS Neuropharmacology (IF 4.7) Pub Date : 2024-02-25 Elena Ortega Martínez, Ma Encarnación Morales Hernández, Julia Castillo-González, Elena González-Rey, Ma Adolfina Ruiz Martínez
Dopamine is unable to access the central nervous system through the bloodstream. Only its precursor can do so, and with an effectiveness below 100% of the dose administered, as it is metabolized before crossing the blood-brain barrier. In this study, we describe a new solid lipid nanocarrier system designed and developed for dopamine. The nanoparticles were prepared by the melt-emulsification method
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Lights at night mediate depression-like behavioral and molecular phenotypes in a glucocorticoid-dependent manner in male rats Neuropharmacology (IF 4.7) Pub Date : 2024-02-23 Zhenlong Li, Chau-Shoun Lee, Hsien-Yu Peng, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Dylan Chou
Nocturnal light pollution, an underappreciated mood manipulator, disturbs the circadian rhythms of individuals in modern society. Preclinical and clinical studies have suggested that exposure to lights at night (LANs) results in depression-like phenotypes. However, the mechanism underlying the action of LANs remains unclear. Therefore, this study explored the potential influence of LANs on depression-related
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Sex-specific effects of sucrose withdrawal on anxiety-like behavior and neuroimmune response Neuropharmacology (IF 4.7) Pub Date : 2024-02-23 Mohit Kumar, Chitralekha Gusain, Babita Bhatt, Roshan Lal, Mahendra Bishnoi
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Repeated cannabidiol treatment affects neuroplasticity and endocannabinoid signaling in the prefrontal cortex of the Flinders Sensitive Line (FSL) rat model of depression. Neuropharmacology (IF 4.7) Pub Date : 2024-02-23 Luana Barreto Domingos, Heidi Kaastrup Müller, Nicole Rodrigues da Silva, Michaela D. Filiou, Anders Lade Nielsen, Francisco Silveira Guimarães, Gregers Wegener, Sâmia Joca
Delayed therapeutic responses and limited efficacy are the main challenges of existing antidepressant drugs, thereby incentivizing the search for new potential treatments. Cannabidiol (CBD), non-psychotomimetic component of cannabis, has shown promising antidepressant effects in different rodent models, but its mechanism of action remains unclear. Herein, we investigated the antidepressant-like effects
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The NMDA receptor modulator zelquistinel durably relieves behavioral deficits in three mouse models of autism spectrum disorder Neuropharmacology (IF 4.7) Pub Date : 2024-02-22 Mathieu Fonteneau, Agathe Brugoux, Déborah Jaccaz, John E. Donello, Pradeep Banerjee, Julie Le Merrer, Jérôme AJ. Becker
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders characterized by deficient social communication and interaction together with restricted, stereotyped behaviors. Currently approved treatments relieve comorbidities rather than core symptoms. Since excitation/inhibition balance and synaptic plasticity are disrupted in ASD, molecules targeting excitatory synaptic transmission appear
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Sex differences in the rodent medial prefrontal cortex – What Do and Don't we know? Neuropharmacology (IF 4.7) Pub Date : 2024-02-20 M.A. Laine, E.M. Greiner, R.M. Shansky
The prefrontal cortex, particularly its medial subregions (mPFC), mediates critical functions such as executive control, behavioral inhibition, and memory formation, with relevance for everyday functioning and psychopathology. Despite broad characterization of the mPFC in multiple model organisms, the extent to which mPFC structure and function vary according to an individual's sex is unclear – a knowledge
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Pharmacological blockage of NOP receptors decreases ventral tegmental area dopamine neuronal activity through GABAB receptor-mediated mechanism Neuropharmacology (IF 4.7) Pub Date : 2024-02-15 Michele Petrella, Anna Maria Borruto, Lorenzo Curti, Ana Domi, Esi Domi, Li Xu, Estelle Barbier, Alice Ilari, Markus Heilig, Friedbert Weiss, Guido Mannaioni, Alessio Masi, Roberto Ciccocioppo
The Nociceptin/Orphanin FQ (N/OFQ) peptide and its receptor NOP are highly expressed within several regions of the mesolimbic system, including the ventral tegmental area (VTA). Evidence indicates that the N/OFQ-NOP receptor system is involved in reward processing and historically it has been proposed that activation of NOP receptors attenuates the motivation for substances of abuse. However, recent
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Postweaning stress affects behavior, brain and gut microbiota of adolescent mice in a sex-dependent manner Neuropharmacology (IF 4.7) Pub Date : 2024-02-13 Xueyong Yin, Ye Zhao, Shuang Wang, Hao Feng, Xinyue He, Xincheng Li, Xiaoyu Liu, Hengtai Lu, Di Wen, Yun Shi, Haishui Shi
Aggression is an instinctive behavior that has been reported to be influenced by early-life stress. However, the potential effects of acute stress during the postweaning period, a key stage for brain development, on defensive aggression and the associated mechanism remain poorly understood. In the present study, aggressive behaviors were evaluated in adolescent mice exposed to postweaning stress. Serum
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MUFA synthesis and stearoyl-CoA desaturase as a new pharmacological target for modulation of lipid and alpha-synuclein interaction against Parkinson's disease synucleinopathy Neuropharmacology (IF 4.7) Pub Date : 2024-02-10 Joanna Kula, Katarzyna Z. Kuter
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Impact of caloric restriction on oxidative stress and key glycolytic enzymes in the cerebral cortex, liver and kidney of old and middle-aged mice Neuropharmacology (IF 4.7) Pub Date : 2024-02-09 Myroslava V. Vatashchuk, Viktoriia V. Hurza, Nadiia Stefanyshyn, Maria M. Bayliak, Dmytro V. Gospodaryov, Olga Garaschuk, Volodymyr I. Lushchak
Caloric restriction (CR) is proposed as a strategy to prevent age-related alterations as impaired glucose metabolism and intensification of oxidative stress. In this study, we examined effects of aging and CR on the activities of glycolytic enzymes and parameters of oxidative stress in the cerebral cortex, liver, and kidney of middle-aged (9 months old) and old (18 months old) C57BL6/N mice. Control
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Sleep loss disrupts decision-making ability and neuronal cytomorphology in zebrafish and the effects are mediated by noradrenaline acting on α1-adrenoceptor Neuropharmacology (IF 4.7) Pub Date : 2024-02-07 Kumar Abhishek, Birendra Nath Mallick
Sleep is an instinct behavior, and its significance and functions are still an enigma. It is expressed throughout one's life and its loss affects psycho-somatic and physiological processes. We had proposed that it might maintain a fundamental property of the neurons and the brain. In that context, it was shown that sleep, rapid eye movement sleep (REMS) in particular, by regulating noradrenaline (NA)
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Optogenetic stimulation of corticostriatal circuits improves behavioral flexibility in mice with prenatal alcohol exposure Neuropharmacology (IF 4.7) Pub Date : 2024-02-07 Valentina Licheri, Jayapriya Chandrasekaran, Johnny A. Kenton, Clark W. Bird, C. Fernando Valenzuela, Jonathan L. Brigman
Fetal alcohol spectrum disorder (FASD) is the most common preventable form of developmental and neurobehavioral disability. Animal models have demonstrated that even low to moderate prenatal alcohol exposure (PAE) is sufficient to impair behavioral flexibility in multiple domains. Previously, utilizing a moderate limited access drinking in the dark paradigm, we have shown that PAE 1) impairs touchscreen
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Corrigendum to “Oxytocinergic neurons, but not oxytocin, are crucial for male penile erection” [Neuropharmacol. 235 (2023) 109576] Neuropharmacology (IF 4.7) Pub Date : 2024-02-06 Yu-Xiang Wen, Lin-Yao Fan, An-Yong Yang, Yan-Chufei Zhang, Chang Xu, Zi-Hui Wang, Wen-Jiong Xie, Yang Lu, Xiao-Yang Zhang, Jing-Ning Zhu, Anyang Sun, Liang Li, Qi-Peng Zhang
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Sex differences in risk-based decision-making and the modulation of risk preference by dopamine-2 like receptors in rats Neuropharmacology (IF 4.7) Pub Date : 2024-02-06 Samantha M. Ayoub, Avraham M. Libster, Samuel A. Barnes, Stephanie C. Dulawa, Jared W. Young
Heightened risk-based decision-making is observed across several neuropsychiatric disorders including schizophrenia, bipolar disorder, and Parkinson's disease, yet no treatments exist that effectively normalize this aberrant behavior. Preclinical risk-based decision-making paradigms have identified the important modulatory roles of dopamine and sex in the performance of such tasks, though specific
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DHEC mesylate attenuates pathologies and aberrant bisecting N-glycosylation in Alzheimer's disease models Neuropharmacology (IF 4.7) Pub Date : 2024-02-06 Yue Wang, Yiming Cao, Hongfei Huang, Yue Xue, Song Chen, Xiangdong Gao
Tremendous progress has been made to develop the therapy of Alzheimer's disease (AD). Existing several anti-AD remedies, with certain limitations, are far from adequate. Evidence suggests that dihydroergocristine (DHEC) mesylate, one of the main components of Ergoloid mesylates, can reduce the production of amyloid-β in vitro. However, the therapeutic effect of DHEC mesylate in AD and its underlying
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Effects of the adenosine A2A receptor antagonist KW6002 on the dopaminergic system, motor performance, and neuroinflammation in a rat model of Parkinson's disease Neuropharmacology (IF 4.7) Pub Date : 2024-02-05 Kavya Prasad, Erik F.J. de Vries, Esther van der Meiden, Rodrigo Moraga-Amaro, Daniel Aaron Vazquez-Matias, Lara Barazzuol, Rudi A.J.O. Dierckx, Aren van Waarde
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Adolescent intermittent ethanol exposure decreases perineuronal nets in the hippocampus in a sex dependent manner: Modulation through pharmacological inhibition of RPTPβ/ζ Neuropharmacology (IF 4.7) Pub Date : 2024-01-29 Milagros Galán-Llario, Esther Gramage, Alba García-Guerra, Abraham B. Torregrosa, Ani Gasparyan, Daniela Navarro, Francisco Navarrete, María Salud García-Gutiérrez, Jorge Manzanares, Gonzalo Herradón
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Novel aspects of signal processing in lamina I Neuropharmacology (IF 4.7) Pub Date : 2024-01-28 Boris V. Safronov, Peter Szucs
The most superficial layer of the spinal dorsal horn, lamina I, is a key element of the nociceptive processing system. It contains different types of projection neurons (PNs) and local-circuit neurons (LCNs) whose functional roles in the signal processing are poorly understood. This article reviews recent progress in elucidating novel anatomical features and physiological properties of lamina I PNs
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Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner Neuropharmacology (IF 4.7) Pub Date : 2024-01-20 Charles L. Ford, Anna A. McDonough, Kengo Horie, Larry J. Young
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Potentiation of prefrontal cortex dopamine function by the novel cognitive enhancer d-govadine Neuropharmacology (IF 4.7) Pub Date : 2024-01-18 Maya O. Nesbit, Soyon Ahn, Haiyan Zou, Stan B. Floresco, Anthony G. Phillips
Cognitive impairment is a debilitating feature of psychiatric disorders including schizophrenia, mood disorders and substance use disorders for which there is a substantial lack of effective therapies. d-Govadine (d-GOV) is a tetrahydroprotoberberine recently shown to significantly enhance working memory and behavioural flexibility in several prefrontal cortex (PFC)-dependent rodent tasks. d-GOV potentiates
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Valence-dependent effects of neuropeptide Y on the expression of conditioned fear and anxiety-like behavior: Involvement of the bed nucleus of the stria terminalis Neuropharmacology (IF 4.7) Pub Date : 2024-01-11 Johannes Kornhuber, Iulia Zoicas
Neuropeptide Y (NPY) has anxiolytic-like effects and facilitates the extinction of cued and contextual fear in rodents. We have previously shown that intracerebroventricular administration of NPY reduces the expression of social fear via simultaneous activation of Y1 and Y2 receptors in a mouse model of social fear conditioning (SFC). In the present study, we investigated whether the anteroventral
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Inhibition of resurgent Na+ currents by rufinamide Neuropharmacology (IF 4.7) Pub Date : 2024-01-14 Jian-Lin Chen, Chung-Chin Kuo
Na+ channels are essential for the genesis of action potentials in most neurons. After opening by membrane depolarization, Na+ channels enter a series of inactivated states (e.g. the fast, intermediate, and slow inactivated states; or If, Ii, and Is). The inactivated Na+ channel may recover via the open state upon membrane repolarization, giving rise to “resurgent” Na+ currents which could be critical
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Stress inoculation during adolescence attenuates social stress-induced increase in ethanol intake in adult male mice Neuropharmacology (IF 4.7) Pub Date : 2024-01-08 Marina D. Reguilón, Carmen Manzanedo, José Miñarro, Marta Rodríguez-Arias
Social stress exposure heightens the risk of substance abuse disorder development, especially when endured during adolescence, influencing long-term mental health. This study investigates early-life stress's potential to confer resilience against later-life stressors. To investigate this hypothesis, we examined the impact of a single social defeat (SD) incident during adolescent mice's lives on subsequent
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Roflupram alleviates autophagy defects and reduces mutant hSOD1-induced motor neuron damage in cell and mouse models of amyotrophic lateral sclerosis Neuropharmacology (IF 4.7) Pub Date : 2024-01-12 Di Huo, Weiwei Liang, Di Wang, Qiaochu Liu, Hongyong Wang, Ying Wang, Chunting Zhang, Chaohua Cong, Xiaoli Su, Xingli Tan, Wenmo Zhang, Ling Han, Dongmei Zhang, Ming Wang, Honglin Feng
Amyotrophic lateral sclerosis (ALS) is a fatal and incurable disease involving motor neuron (MN) degeneration and is characterized by ongoing myasthenia and amyotrophia in adults. Most ALS patients die of respiratory muscle paralysis after an average of 3–5 years. Defective autophagy in MNs is considered an important trigger of ALS pathogenesis. Roflupram (ROF) was demonstrated to activate autophagy
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Dynamic effects of ventral hippocampal NRG3/ERBB4 signaling on nicotine withdrawal-induced responses Neuropharmacology (IF 4.7) Pub Date : 2024-01-09 Miranda L. Fisher, Emily R. Prantzalos, Bernadette O'Donovan, Tanner L. Anderson, Pabitra K. Sahoo, Jeffery L. Twiss, Pavel I. Ortinski, Jill R. Turner
Tobacco smoking remains a leading cause of preventable death in the United States, with approximately a 5% success rate for smokers attempting to quit. High relapse rates have been linked to several genetic factors, indicating that the mechanistic relationship between genes and drugs of abuse is a valuable avenue for the development of novel smoking cessation therapies. For example, various single
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Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration Neuropharmacology (IF 4.7) Pub Date : 2024-01-03 Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qin
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BNC210, a negative allosteric modulator of the alpha 7 nicotinic acetylcholine receptor, demonstrates anxiolytic- and antidepressant-like effects in rodents Neuropharmacology (IF 4.7) Pub Date : 2024-01-06 Susan M. O'Connor, Brad E. Sleebs, Ian P. Street, Bernard L. Flynn, Jonathan B. Baell, Carolyn Coles, Nurul Quazi, Dharam Paul, Etienne Poiraud, Bertrand Huyard, Stephanie Wagner, Emile Andriambeloson, Errol B. de Souza
This work describes the characterization of BNC210 (6-[(2,3-dihydro-1H-inden-2-yl)amino]-1-ethyl-3-(4-morpholinylcarbonyl)-1,8-naphthyridin-4(1H)-one), a selective, small molecule, negative allosteric modulator (NAM) of α7 nicotinic acetylcholine receptors (α7 nAChR). With the aim to discover a non-sedating, anxiolytic compound, BNC210 was identified during phenotypic screening of a focused medicinal
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Requisite role of dorsal raphé in contextual cocaine-memory reconsolidation Neuropharmacology (IF 4.7) Pub Date : 2024-01-03 J.L. Ritchie, S. Qi, R.J. Christian, M.J. Greenwood, H.I. Grenz, S.E. Swatzell, P.J. Krych, R.A. Fuchs
Memory reconsolidation is a process by which labile drug memories are restabilized in long-term memory stores, permitting their enduring control over drug-seeking behaviors. In the present study, we investigated the involvement of the dorsal raphé nuclei (DRN) in cocaine-memory reconsolidation. Sprague-Dawley rats (male, female) were trained to self-administer cocaine in a distinct environmental context
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Phosphoproteomics implicates glutamatergic and dopaminergic signalling in the antidepressant-like properties of the iron chelator deferiprone Neuropharmacology (IF 4.7) Pub Date : 2024-01-04 Volkan Uzungil, Sandra Luza, Carlos M. Opazo, Isaline Mees, Shanshan Li, Ching-Seng Ang, Nicholas A. Williamson, Ashley I. Bush, Anthony J. Hannan, Thibault Renoir
Background Current antidepressants have limitations due to insufficient efficacy and delay before improvement in symptoms. Polymorphisms of the serotonin transporter (5-HTT) gene have been linked to depression (when combined with stressful life events) and altered response to selective serotonergic reuptake inhibitors. We have previously revealed the antidepressant-like properties of the iron chelator
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Cannabidiol as a potential cessation therapeutic: Effects on intravenous nicotine self-administration and withdrawal symptoms in mice Neuropharmacology (IF 4.7) Pub Date : 2024-01-03 Samantha N. Cheeks, Belle Buzzi, Ashley Valdez, Allison S. Mogul, M. Imad Damaj, Christie D. Fowler
Cigarette smoking remains a leading cause of preventable disease and death worldwide. Due to the devastating negative health effects of smoking, many users attempt to quit, but few are successful in the long-term. Thus, there is a critical need for novel therapeutic approaches. In these investigations, we sought to examine whether cannabidiol (CBD) has the potential to be repurposed as a nicotine cessation
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Sex specific effects of buprenorphine on adult hippocampal neurogenesis and behavioral outcomes during the acute phase after pediatric traumatic brain injury in mice Neuropharmacology (IF 4.7) Pub Date : 2023-12-29 Ivan Davila-Valencia, Mark Saad, Grace Olthoff, Megan Faulkner, Maysoun Charara, Abigail Farnum, Robert C. Dysko, Zhi Zhang
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Mitotherapy prevents peripheral neuropathy induced by oxaliplatin in mice Neuropharmacology (IF 4.7) Pub Date : 2023-12-27 João R.L. C.B. Maia, Loreena K.A. Machado, Gabriel G. Fernandes, Louise C. Vitorino, Letícia S. Antônio, Suzana Maria B. Araújo, Lilian C. Colodeti, Fabrícia L. Fontes-Dantas, Julianna D. Zeidler, Georgia N. Saraiva, Andrea T. Da Poian, Claudia P. Figueiredo, Giselle F. Passos, Robson da Costa
Oxaliplatin (OXA) is an antineoplastic agent used for the treatment of cisplatin-resistant tumours, presenting lower incidence of nephrotoxicity and myelotoxicity than other platinum-based drugs. However, OXA treatment is highly associated with painful peripheral neuropathy, a well-known and relevant side effect caused by mitochondrial dysfunction. The transfer of functional exogenous mitochondria
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Structure-activity relationships for locomotor stimulant effects and monoamine transporter interactions of substituted amphetamines and cathinones Neuropharmacology (IF 4.7) Pub Date : 2023-12-27 Lauren R. Fitzgerald, Brenda M. Gannon, Donna Walther, Antonio Landavazo, Takato Hiranita, Bruce E. Blough, Michael H. Baumann, William E. Fantegrossi
Substitutions to the phenethylamine structure give rise to numerous amphetamines and cathinones, contributing to an ever-growing number of abused novel psychoactive substances. Understanding how various substitutions affect the pharmacology of phenethylamines may help lawmakers and scientists predict the effects of newly emerging drugs. Here, we established structure-activity relationships for locomotor
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The anterior cingulate cortex and its interface with the dorsal periaqueductal grey regulating nitric oxide-mediated panic-like behaviour and defensive antinociception Neuropharmacology (IF 4.7) Pub Date : 2023-12-30 Luiz Luciano Falconi-Sobrinho, Tayllon dos Anjos-Garcia, Macário Arosti Rebelo, Paloma Molina Hernandes, Rafael Carvalho Almada, Jose Eduardo Tanus-Santos, Norberto Cysne Coimbra
The anterior cingulate cortex (ACC) Cg1 (24b) area modulates glutamate-mediated unconditioned fear and antinociception organised by hypothalamus. However, it remains unknown whether 24b area also modulates these latter defensive responses through connections with the dorsal periaqueductal grey matter (dPAG), a midbrain structure implicated in the genesis of innate fear-induced defence. The aim of this
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Activation of 5-HT5A receptor in the ventrolateral orbital cortex produces antinociceptive effects in rat models of neuropathic and inflammatory pain Neuropharmacology (IF 4.7) Pub Date : 2023-12-29 Yu-Long Zhao, Jia-Liang Xu, Hui-Yuan Yi, Sani Sa'idu Baba, Yi-Xiao Guo, Xue-Mei Hou, Xiao-Cui Yuan, Xu-Hui Li, Yu-Ying Wang, Ling-Li Liang, Fu-Quan Huo
The ventrolateral orbital cortex (VLO) is identified as an integral component of the endogenous analgesic system comprising a spinal cord - thalamic nucleus submedius - VLO - periaqueductal gray (PAG) - spinal cord loop. The present study investigates the effects of 5-HT5A receptor activation in the VLO on allodynia induced by spared nerve injury and formalin-evoked flinching behavior and spinal c-Fos
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Editorial - Purinergic Signalling: 50 years Neuropharmacology (IF 4.7) Pub Date : 2023-12-20 Peter Illes, Francesco Di Virgilio, Yong Tang
The function of almost all cells of the human and animal body is synchronized by purinergic/pyrimidinergic extracellular signaling molecules. This network activity is especially efficient in the central and peripheral nervous systems, driven by secretion of the (co)transmitter ATP (including its enzymatic degradation products ADP, AMP, and adenosine), as well as ATP/UTP (including UDP) released from
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P2Y13 receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation Neuropharmacology (IF 4.7) Pub Date : 2023-12-22 Sui Yin, Xuexuan Yang, Honglei Li, Chenxi Li, Changyi Li, Chengxu Chen, Shang Ye, Lifang Zou, Shangdong Liang, Shuangmei Liu
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Impacts of xylazine on fentanyl demand, body weight, and acute withdrawal in rats: A comparison to lofexidine Neuropharmacology (IF 4.7) Pub Date : 2023-12-20 Safiyah M. Sadek, Shailesh N. Khatri, Zachary Kipp, Kelly E. Dunn, Joshua S. Beckmann, William W. Stoops, Terry D. Hinds, Cassandra D. Gipson
The opioid use landscape has recently shifted to include xylazine, a veterinary anesthetic, as an adulterant in the fentanyl supply. The health impacts of xylazine as an emerging fentanyl adulterant has raised alarm regarding xylazine as a public health threat, warranting research on the impacts of xylazine on fentanyl's behavioral effects. No prior studies have evaluated the effects of xylazine on
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Defective autophagy contributes to bupivacaine-induced aggravation of painful diabetic neuropathy in db/db mice Neuropharmacology (IF 4.7) Pub Date : 2023-12-15 Keke Fan, Qinming Liao, Pengfei Yuan, Rui Xu, Zhongjie Liu
Current evidence suggests that hyperactivated or impaired autophagy can lead to neuronal death. The effect of local anesthetics on painful diabetic neuropathy (PDN) and the role of autophagy in the above pathological process remain unclear, warranting further studies. So, PDN models were established by assessing the paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) in leptin gene-mutation
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Clinical usefulness of dual orexin receptor antagonism beyond insomnia: Neurological and psychiatric comorbidities Neuropharmacology (IF 4.7) Pub Date : 2023-12-17 Matteo Carpi, Laura Palagini, Mariana Fernandes, Carmen Calvello, Pierre Alexis Geoffroy, Mario Miniati, Stefano Pini, Angelo Gemignani, Nicola Biagio Mercuri, Claudio Liguori
Orexin is a neurotransmitter produced by a small group of hypothalamic neurons. Besides its well-known role in the regulation of the sleep-wake cycle, the orexin system was shown to be relevant in several physiological functions including cognition, mood and emotion modulation, and energy homeostasis. Indeed, the implication of orexin neurotransmission in neurological and psychiatric diseases has been
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Infliximab alleviates memory impairment in rats with chronic pain by suppressing neuroinflammation and restoring hippocampal neurogenesis Neuropharmacology (IF 4.7) Pub Date : 2023-12-16 Rui Yao, Yuanyuan Man, Yao Lu, Yang Su, Meiyan Zhou, Shuang Wang, Xiaoping Gu, Rongguo Wang, Yuqing Wu, Liwei Wang
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P2X receptor- and postsynaptic NMDA receptor-mediated long-lasting facilitation of inhibitory synapses in the rat insular cortex Neuropharmacology (IF 4.7) Pub Date : 2023-12-16 Kiyofumi Yamamoto, Satoshi Kosukegawa, Masayuki Kobayashi
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Network-based analysis on the genes and their interactions reveals link between schizophrenia and Alzheimer's disease Neuropharmacology (IF 4.7) Pub Date : 2023-12-01 Pan Guo, Chao Meng, Shuyue Zhang, Yingzi Cai, Junkai Huang, Jianbo Shu, Ju Wang, Chunquan Cai
Schizophrenia (SCZ) is a heterogeneous psychiatric disorder marked by impaired thinking, emotions, and behaviors. Studies have suggested a strong connection between SCZ and Alzheimer's disease (AD), however, controversies exist and the underlying mechanisms linking these two disorders remain largely unknown. Therefore, systematic studies of SCZ- and AD-related genes will provide valuable insights into