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Exploring the potential of P-glycoprotein inhibitors in the targeted delivery of anti-cancer drugs: A comprehensive review Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-20 Dhvani Patel, Nutan Sethi, Paresh Patel, Shreeraj Shah, Kaushika Patel
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Lipid nanoparticles for local delivery of mRNA to the respiratory tract: Effect of PEG-lipid content and administration route Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-16 Melike Ongun, Abhijeet Girish Lokras, Saahil Baghel, Zhenning Shi, Signe Tandrup Schmidt, Henrik Franzyk, Thomas Rades, Federica Sebastiani, Aneesh Thakur, Camilla Foged
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Meta-analysis guided development of a standard artificial urine Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-16 Kimberley A. Noble, Hayley K.Y. Chan, Oisín N. Kavanagh
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Don’t shake it! Mechanical stress testing of mRNA-lipid nanoparticles Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-15 Anna Ruppl, Denis Kiesewetter, Franziska Strütt, Monika Köll-Weber, Regine Süss, Andrea Allmendinger
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Reducing hydrophobic drug adsorption in an in-vitro extracorporeal membrane oxygenation model Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-14 Nitish Khurana, Kamiya Watkins, Debika Ghatak, Jane Staples, Oliver Hubbard, Venkata Yellepeddi, Kevin Watt, Hamidreza Ghandehari
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Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Annika Valtari, Susanna Posio, Elisa Toropainen, Anusha Balla, Jooseppi Puranen, Amir Sadeghi, Marika Ruponen, Veli-Pekka Ranta, Kati-Sisko Vellonen, Arto Urtti, Eva M. del Amo
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Phage-Based antibacterial hydrogels for bacterial targeting and Ablation: Progress and perspective Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Haoran Bai, Qinggele Borjihan, Zheng Li, Peiran Qin, Jingli Cheng, Douxin Xiao, Alideertu Dong
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Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Oleg A. Kulikov, Vasilisa I. Shlyapkina, Ekaterina P. Brodovskaya, Amina M. Al-khadj Aioub, Valentin P. Ageev, Mikhail N. Zharkov, Denis E. Yakobson, Daniil S. Sokushev, Nikolay A. Pyataev, Gleb B. Sukhorukov
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Recent advances of ultrasound-responsive nanosystems in tumor immunotherapy Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Penghui Wang, Ji Chen, Runming Zhong, Yuanyuan Xia, Zhina Wu, Chunye Zhang, Hai Yao
Classification of the role of ultrasound in tumor immunotherapy: HIFU, LIFU, ultrasound cavitation, and sonodynamic therapy. Different mechanisms of action produce differentiated immunotherapeutic effects, which can not only directly activate immune factors within the tumor, indirectly induce the generation of microbubbles to promote the delivery of immunotherapeutic agents, but also non-invasively
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Synthesis of folate targeted theranostic cubosomal platform for co-delivery of bismuth oxide and doxorubicin to melanoma in vitro and in vivo Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-12 Mahsa Zahiri, Hosein Kamali, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Negar Nekooei, Mohammad Ramezani, Mona Alibolandi
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Cyclodextrin microneedles for the delivery of a nanoparticle-based peptide antigen vaccine Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-11 Silvana Geisshüsler, Frida A. Nilsson, Nicole Ziak, Zuzanna Kotkowska, Marta Paolucci, Marina Green Buzhor, Nicole Zoratto, Pål Johansen, Jean-Christophe Leroux
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Antimicrobial peptide A9K as a gene delivery vector in cancer cells Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-11 Silvia Cirillo, Bo Zhang, Stephen Brown, Xiubo Zhao
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Identification of structural origins of complex charge heterogeneity in therapeutic ACE2Fc fusion protein facilitated by free-flow isoelectric focusing Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-10 Lingyu Wang, Hai Wu, Ting Cao, Hongyang Li, Pengcheng Shen, Lihong Lu, Zhongli Zhang
Fc Fusion protein represents a versatile molecular platform with considerable potential as protein therapeutics of which the charge heterogeneity should be well characterized according to regulatory guidelines. Angiotensin-converting enzyme 2 Fc fusion protein (ACE2Fc) has been investigated as a potential neutralizing agent to various coronaviruses, including the lingering SARS-CoV-2, as this coronavirus
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Effect of in vitro transcription conditions on yield of high quality messenger and self-amplifying RNA Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-09 Petya G. Popova, Melissa A. Lagace, George Tang, Anna K. Blakney
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Toward the boosted loading of cisplatin drug into liposome nanocarriers Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-06 Anna M. Wróblewska, Ewelina Łukawska, Zuzanna Wakuła, Joanna Zajda, Bernhard K. Keppler, Andrei R. Timerbaev, Magdalena Matczuk
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Preparation of etoposide liposomes for enhancing antitumor efficacy on small cell lung cancer and reducing hematotoxicity of drugs Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-06 Ruixue Huang, Huali Chen, Damao Pi, Xuemei He, Chao Yu, Chaoqun Yu
Etoposide liposomes (VP16-LPs) incorporating DSPE-mPEG2000 were prepared and further made into freeze-dried powder. After intravenous injection, VP16-LPs enhanced antitumor effects on small cell lung cancer and reduced toxicity of drugs compared with marketed VP16 injection.
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Tailoring lipid nanoparticles for T-cell targeting in allergic asthma: Insights into efficacy and specificity Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-03 David C. Jürgens, Joschka T. Müller, Anny Nguyen, Olivia M. Merkel
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Development of an in vitro co-culture model using Caco-2 and J774A.1 cells to mimic intestinal inflammation Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-02 Mona Belaid, Jana Javorovic, Giorgia Pastorin, Driton Vllasaliu
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On the uncertainty of the correlation between nanoparticle avidity and biodistribution Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-02 Oliver Zimmer, Achim Goepferich
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Supersaturable diacyl phospholipid dispersion for improving oral bioavailability of brick dust molecule: A case study of Aprepitant Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-03-01 Ajay Sanjay Lale, Arvind Sirvi, Shubham Debaje, Sadhana Patil, Abhay T. Sangamwar
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A systematic investigation of external lubrication of mini-tablets on a rotary tablet press with focus on the tensile strength Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-28 Valentinë Lura, Stefan Klinken, Jörg Breitkreutz
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Development of cationic solid lipid nanoparticles incorporating cholesteryl-9-carboxynonanoate (9CCN) for delivery of antagomiRs to macrophages Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-27 Adrian Mallén, David A. Narváez-Narváez, M.D. Pujol, Estanis Navarro, Josep Maria Suñé-Negre, Encarna García-Montoya, Pilar Pérez-Lozano, Benjamín Torrejón-Escribano, Marc Suñé-Pou, Miguel Hueso
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Minimizing pain in deer antler removal: Local anaesthetics in ZnO nanoparticle based collagen dressings as a promising solution Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-24 Farzin Sahebjam, Paul Chambers, Kavitha Kongara, Yi Zhang, Nicholas Lopez, Antony Jacob, Preet Singh, Sujay Prabakar
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Analytical techniques for the characterization of nanoparticles for mRNA delivery Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-23 Sara S. Nogueira, Eleni Samaridou, Johanna Simon, Simon Frank, Moritz Beck-Broichsitter, Aditi Mehta
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RNA-encapsulating lipid nanoparticles in cancer immunotherapy: From pre-clinical studies to clinical trials Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-23 Tiffaney Hsia, Yunching Chen
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Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6 Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-22 Maximilian Walther, Robert Jenke, Achim Aigner, Alexander Ewe
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Kinetics of RNA-LNP delivery and protein expression Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-20 Judith A. Müller, Nathalie Schäffler, Thomas Kellerer, Gerlinde Schwake, Thomas S. Ligon, Joachim O. Rädler
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Azithromycin-loaded liposomes and niosomes for the treatment of skin infections: Influence of excipients and preparative methods on the functional properties Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-20 A. Abruzzo, R. Pucci, P.M. Abruzzo, S. Canaider, C. Parolin, B. Vitali, F. Valle, M. Brucale, T. Cerchiara, B. Luppi, F. Bigucci
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Long acting tariquidar loaded stearic acid-modified hydroxyapatite enhances brain penetration and antitumor effect of temozolomide Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-19 Cheng-Ping Yu, Shang-Wen Lin, Jui-Chen Tsai, Yan-Jye Shyong
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Advancing injection force modeling and viscosity-dependent injectability evaluation for prefilled syringes Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-18 Linke Wu, Hui Li, Yunyun Wang, Chengyu Liu, Zhixin Zhao, Guisheng Zhuang, Quanmin Chen, Weichang Zhou, Jeremy Guo
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Lipid nanoparticles containing labile PEG-lipids transfect primary human skin cells more efficiently in the presence of apoE Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-17 Camilla Hald Gregersen, Razan Mearraoui, Pia Pernille Søgaard, Gael Clergeaud, Karsten Petersson, Andrew J. Urquhart, Jens B. Simonsen
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Assessing Abuse-Deterrent formulations utilizing Ion-Exchange resin complexation processed via Twin-Screw granulation for improved safety and effectiveness Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-17 Siva Ram Munnangi, Nagarjuna Narala, Preethi Lakkala, Sateesh Kumar Vemula, Michael Repka
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Rapid characterization of physical properties for the pharmaceutical pellet cores based on NIR spectroscopy and ensemble learning Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Sijun Wu, Chaoliang Jia, Li Wang, Cheng Ye, Zheng Li, Wenlong Li
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Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Pieterjan Merckx, Griet Conickx, Evy Blomme, Tania Maes, Ken R. Bracke, Guy Brusselle, Stefaan C. De Smedt, Koen Raemdonck
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Exosome-based WTAP siRNA delivery ameliorates myocardial ischemia-reperfusion injury Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-15 Tao Yin, Ning Wang, Fang Jia, Yuchao Wu, Lei Gao, Jing Zhang, Rongrong Hou
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Personalised oral dosage forms using an ultra-compact tablet press at the point of care Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-14 Ingo Krause, Rene Manigk, Elena Arribas Lopez, Dennis Douroumis
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Reply to comments by Dr. Ali Shayanfar Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-12 Han Hao, Jing Wang
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Comments on “Cocrystallization of 5-fluorouracil with gallic acid: A novel 5-fluorouracil cocrystal displaying synergistic anti-tumor activity both in oral and intraperitoneal injection administration” Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-12 Raha Kaviani, Amin Alvani, Ali Shayanfar
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The role of phospholipids in drug delivery formulations – Recent advances presented at the Researcher’s Day 2023 Conference of the Phospholipid Research Center Heidelberg Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-11 Richard Wibel, Peter van Hoogevest, Simon Drescher
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Archaeal ether lipids improve internalization and transfection with mRNA lipid nanoparticles Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-10 Viktor Laurin Sedlmayr, Silvia Schobesberger, Sarah Spitz, Peter Ertl, David Johannes Wurm, Julian Quehenberger, Oliver Spadiut
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In situ triggered, floating delivery systems of capsaicin for prolonged gastroprotection Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-10 Konstantina Chachlioutaki, Pedro H.D.M. Prazeres, Sérgio R.A. Scalzo, Pelagia Bakirtzi, Samson Afewerki, Pedro P.G. Guimaraes, Nikolaos Bouropoulos, Dimitrios G. Fatouros, Christina Karavasili
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Enhanced anti-malarial efficacy of mefloquine delivered via cationic liposome in a murine model of experimental cerebral malaria Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-09 Mohsin Raza, Hina Bharti, Charu Chauhan, Aakriti Singal, Deepa Jha, Prahlad C. Ghosh, Alo Nag
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Evidence of the protective effect of anti-pollution products against oxidative stress in skin ex vivo using EPR spectroscopy and autofluorescence measurements Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-08 Phuong Thao Tran, Johannes Schleusener, Burkhard Kleuser, Katinka Jung, Martina C. Meinke, Silke B. Lohan
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Combination of self-assembling system and N,O-carboxymethyl chitosan improves ocular residence of anti-glaucoma drug Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-07 Velmurugan Kailasam, Bommanahalli Nagaraju Kumara, K. Sudhakara Prasad, Jayabalan Nirmal
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Polymeric microneedles for the eye: An overview of advances and ocular applications for minimally invasive drug delivery Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-07 Madhura Mulkutkar, Mansi Damani, Sujata Sawarkar
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Comparative analysis of lipid Nanoparticle-Mediated delivery of CRISPR-Cas9 RNP versus mRNA/sgRNA for gene editing in vitro and in vivo Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-06 Johanna Walther, Deja Porenta, Danny Wilbie, Cornelis Seinen, Naomi Benne, Qiangbing Yang, Olivier Gerrit de Jong, Zhiyong Lei, Enrico Mastrobattista
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Drug solubility in biorelevant media in the context of an inhalation-based biopharmaceutics classification system (iBCS) Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-03 Andreea Floroiu, Brigitta Loretz, Johannes Krämer, Claus-Michael Lehr
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Fexofenadine-loaded chitosan coated solid lipid nanoparticles (SLNs): A potential oral therapy for ulcerative colitis Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-03 Walaa A. El-Dakroury, Moataz B. Zewail, Gihan F. Asaad, Heba M.I. Abdallah, Marwa E. Shabana, Abdelrahman R. Said, Ahmed S. Doghish, Hadeer A. Azab, Dalia H. Amer, Ahmed E. Hassan, Alaa S. Sayed, Ghada M. Samra, Al-Aliaa M. Sallam
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Efficient cocrystal coformer screening based on a Machine learning Strategy: A case study for the preparation of imatinib cocrystal with enhanced physicochemical properties Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-02 Xiaoxiao Liang, Shiyuan Liu, Zebin Li, Yuehua Deng, Yanbin Jiang, Huaiyu Yang
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Preparation and formulation of progesterone para-aminobenzoic acid co-crystals with improved dissolution and stability Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-02 Thomas Hibbard, Kenneth Shankland, Hisham Al-Obaidi
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Less is more: Self-amplifying mRNA becomes self-killing upon dose escalation in immune-competent retinal cells Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-01 Helena Vanluchene, Oriane Gillon, Karen Peynshaert, Stefaan C. De Smedt, Niek Sanders, Koen Raemdonck, Katrien Remaut
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Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-02-01 Marwa G. Elnaggar, Yanying He, Yoon Yeo
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L-carnitine modified nanoparticles target the OCTN2 transporter to improve the oral absorption of jujuboside B Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-26 Wei Li, Yanqing Zhang, Jing Zhao, Tan Yang, Junbo Xie
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Container-content interactions with radiopharmaceuticals: Seeing is believing Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-28 Typhanie Ladrière, Laura Aussage, Jonathan Vigne
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Lipoprotein-mimicking nanotherapeutics reconstituted with chenodeoxycholic acid modified protein for efficient tumor targeting Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-19 Yunfeng Hu, Jiahui Zou, Qianqian Wang, Yang Chen, Hui Wang, Jin Li
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Sustained release of a human pd-l1 single-domain antibody using peptide-based hydrogels Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-19 Julie Heremans, Robin Maximilian Awad, Jessica Bridoux, Thomas Ertveldt, Vicky Caveliers, Annemieke Madder, Richard Hoogenboom, Nick Devoogdt, Steven Ballet, Sophie Hernot, Karine Breckpot, Charlotte Martin
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Targeted intradermal delivery of alpha-arbutin-loaded dissolving polymeric microneedles visualized by three-dimensional Orbitrap secondary ion mass spectrometry (3D OrbiSIMS) Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-14 Zhiwei Li, Maria Marlow, David Scurr, Zheying Zhu
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Development of an immunosuppressed orthotopic hepatocellular carcinoma rat model for the evaluation of chemo- and radioembolization therapies Eur. J. Pharm. Biopharm. (IF 4.9) Pub Date : 2024-01-16 Lovelyn Charles, Sathiya Sekar, Maryam Osooly, Sumreen Javed, Karla C. Williams, Ian Welch, Ingrid Barta, Katayoun Saatchi, Urs O. Häfeli