This study was aimed to investigate the cardioprotective and antioxidant effect of Vaccinium meridionale Swartz in ischemia-induced male albino Wistar strain rats. Rats were grouped into 5 of 6 numbers each. Group I served as a sham, group II served as control and group III, IV, and V served for 1, 10, and 25 mg/kg/d of an extract of Vaccinium meridionale Swartz for 15 consecutive days of treatment. Serum marker enzymes, lipid peroxidation, and myeloperoxidase were increased, whereas antioxidant enzymes were reduced in control due to injury. Increased phenol and anthocyanin contents and increased free radical scavenging activity was noted following treatment. Serum marker enzymes, necrosis, and lipid peroxidation, were reduced, whereas antioxidant enzymes and reduced glutathione were increased. Nitric oxide synthase and Akt expression were also increased following treatment. Taking all these data together, it is suggested that Vaccinium meridionale Swartz may be a potential therapeutic agent for the treatment of ischemic injury.

中文翻译：

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越桔对缺血再灌注诱导的雄性白化大鼠的体内治疗作用

本研究旨在研究越桔对缺血诱导的雄性白化 ​​Wistar 品系大鼠的心脏保护和抗氧化作用。大鼠被分成5组，每组6个。I 组作为假手术，II 组作为对照，III、IV 和 V 组连续 15 天服用 1、10 和 25 毫克/千克/天的越橘提取物。血清标记酶、脂质过氧化和髓过氧化物酶增加，而抗氧化酶由于损伤而在对照中减少。处理后注意到苯酚和花青素含量增加，自由基清除活性增加。血清标记酶、坏死和脂质过氧化减少，而抗氧化酶和还原型谷胱甘肽增加。处理后一氧化氮合酶和 Akt 表达也增加。综合所有这些数据，表明越桔可能是治疗缺血性损伤的潜在治疗剂。