Background

East Liverpool, Ohio, the site of a hazardous waste incinerator and a manganese (Mn) processor, has had air Mn concentrations exceeding United States Environmental Protection Agency reference levels for over a decade. Save Our County, Inc., a community organization, was formed to address community environmental health concerns related to local industry. Researchers from the University of Cincinnati partnered with Save Our County to determine if air Mn had an impact on the neurocognitive function of children in the community.

Methods

Children 7–9 years of age from East Liverpool and its surrounding communities, were enrolled (N = 106) in the Communities Actively Researching Exposure Study from between March 2013–June 2014. Blood and hair were analyzed for Mn and lead, and serum was analyzed for cotinine. We used linear regression to assess associations between biological measures and IQ subscale scores.

Results

Geometric mean blood lead (n = 67), blood Mn (n = 66), hair Mn (n = 98), and serum cotinine (n = 69) concentrations were 1.13 ± 1.96 μg/dL, 10.06 ± 1.30 μg/L, and 360.22 ± 2.17 ng/g, 0.76 ± 6.12 μg/L respectively. After adjusting for potential confounders, hair Mn was negatively associated with Full Scale IQ.

Conclusions

Hair Mn was negatively associated with child IQ scores. Community partners were instrumental in the conception and implementation of this study.

中文翻译：

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空气锰对俄亥俄州东利物浦儿童神经发育的影响。

背景

俄亥俄州的东利物浦市是危险废物焚烧炉和锰（Mn）处理厂的所在地，十多年来，空气中的锰浓度超过了美国环境保护署的参考水平。成立了社区组织“ Save Our County，Inc.”，以解决与当地行业相关的社区环境健康问题。辛辛那提大学的研究人员与“拯救我们的县”合作，确定了空气中的锰是否对社区儿童的神经认知功能有影响。

方法

从2013年3月至2014年6月，参加了利物浦东部及周边社区7-9岁的儿童（N = 106），参加了社区积极研究接触研究。对血液和头发中的锰和铅进行了分析，并对血清进行了分析。分析可替宁。我们使用线性回归来评估生物学指标和智商量表分数之间的关联。

结果

几何平均血铅（n = 67），血液Mn（n = 66），头发Mn（n = 98）和血清可替宁（n = 69）的浓度分别为1.13±1.96μg/ dL，10.06±1.30μg/ L，和360.22±2.17 ng / g，0.76±6.12μg/ L。调整了潜在的混杂因素后，头发锰与全智商呈负相关。

结论

头发锰与儿童智商得分呈负相关。社区合作伙伴在这项研究的概念和实施中发挥了重要作用。