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Assessment of saliva, hair and toenails as biomarkers of low level exposure to manganese from drinking water in children
NeuroToxicology ( IF 3.4 ) Pub Date : 2017-09-01 , DOI: 10.1016/j.neuro.2017.08.011
Ruth Ntihabose , Céline Surette , Delphine Foucher , Olivier Clarisse , Maryse F. Bouchard

We evaluated hair, toenails, and saliva (whole and supernatant) as biomarkers of exposure to manganese (Mn) in 274 school age children (6–13 years) consuming well water in southeastern New Brunswick, Canada. Mn concentrations in tap water ranged from <0.03 to 1046 μg L−1 (geometric mean 5.96 μg L−1). The geometric mean of Mn intake resulting from the consumption of water was 0.25 (0–34.95) μg kg−1 day−1. Both Mn concentration in water and Mn intake were significantly correlated with Mn in hair (r = 0.60 and r = 0.53, respectively), Mn in toenail (r = 0.29 and r = 0.37 respectively) and to a lesser extent with Mn in saliva supernatant (r = 0.14 and r = 0.18, respectively). Mn in whole saliva did not correlate with Mn in water or Mn intake. Both Mn in hair and Mn in toenail allowed to discriminate the most exposed group from the least exposed group, based on Mn in water and Mn intake from water. In this group of children with low level Mn exposure, Mn concentrations in hair, and toenails reflected reasonably well Mn exposure from drinking water, whereas Mn content in saliva correlated less strongly.



中文翻译:

评估唾液,头发和脚趾甲作为儿童饮用水中低水平接触锰的生物标志物

我们在加拿大新不伦瑞克省东南部的274名学龄儿童(6至13岁)中,他们食用头发,脚趾甲和唾液(全部和上清液)作为接触锰(Mn)的生物标志物(6至13岁)。自来水中的锰浓度范围为<0.03至1046μgL -1(几何平均值为5.96μgL -1)。水消耗引起的锰摄入量的几何平均值为0.25(0–34.95)μgkg -1 天-1。水中的锰浓度和摄入的锰与头发中的锰(分别为r = 0.60和r = 0.53),趾甲中的Mn(分别为r = 0.29和r = 0.37)显着相关,而与唾液上清液中的Mn相关程度较小。 (分别为r = 0.14和r = 0.18)。整个唾液中的锰与水或锰摄入中的锰均不相关。头发中的Mn和脚趾甲中的Mn都可以根据水中的Mn和水中的Mn来区分暴露程度最高的组和暴露程度最低的组。在这组锰暴露水平较低的儿童中,头发和脚趾甲中的锰浓度反映了饮用水中锰的暴露水平,而唾液中锰含量的相关性较低。

更新日期:2017-09-01
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