Abstract Methoxy-modified kaolinite was used as a novel carrier for anticancer drug 5-fluorouracil (5FU). The selective loading of 5FU into the interlayer space of methoxy-modified kaolinite was achieved because the weakly bonded 5FU on the external surface was removed off by facile water rinse. The intercalated 5FU has strong affinity (electrostatic force and hydrogen bonding) with the interlayer surface of kaolinite, and its release was controlled because of the diffusion restriction of the kaolinite lamellar layers and the strong affinity between 5FU and kaolinite. The controlled release of 5FU from methoxy-modified kaolinite in simulated colonic fluid (pH 5.5) makes it be of potential use to administer an oral formulation of 5FU for colon specific delivery.

中文翻译：

---

甲氧基改性高岭石层间空间选择性负载5-氟尿嘧啶控释

摘要 甲氧基改性高岭石被用作抗癌药物5-氟尿嘧啶（5FU）的新型载体。5FU 选择性地加载到甲氧基改性高岭石的层间空间是因为外表面的弱键合 5FU 被轻松的水冲洗掉了。插层的5FU与高岭石层间表面具有很强的亲和力（静电力和氢键），由于高岭石层状层的扩散限制以及5FU与高岭石之间的强亲和力，其释放受到控制。在模拟结肠液 (pH 5.5) 中，甲氧基改性高岭石的 5FU 受控释放使其成为用于结肠特异性递送的 5FU 口服制剂的潜在用途。