Ilex paraguariensis, yerba mate is a native plant from the southern region of Brazil. Studies showed that yerba mate has an antioxidant potential, which could help to reduce the risk of developing neurodegenerative diseases, as Alzheimer's Disease (AD). It's known that I. paraguariensis grows in acid soils with aluminium (Al), which is bioavailable in these soils. Al has a neurotoxic potential related with the progression of neurological disorders. This study aim was to evaluate the potential of I. paraguariensis in the etiology of AD using strains of Caenorhabditis elegans and the concentration of Al and antioxidants in the yerba mate extract. The results of the I. paraguariensis infusions made at 65 °C and at 75° C show that there was no significant difference between both temperatures when preparing the tea infusion in relation to the presence of Al, methylxanthines, phenolic compounds and flavonoids. Additionally, in the case of Al, there was no difference between the extracts prepared at both temperatures. The behavioral parameters of C. elegans were altered after a long-term exposure to both factors: I. paraguariensis extract and Al. Through the antioxidant levels results along with the Al content on the Acetylcholinesterase (AChE) activity it is possible to observe that the acute and chronic exposure to Al and I. paraguariensis leaves extract are very similar to wild-type worms. Moreover, we can observe that the results in both the transgenic strains long-term exposed to I. paraguariensis leaves extract and to the Al concentrations presented an increase in the AChE activity.

巴拉圭冬青树（Ilex paraguariensis）是巴西南部的本地植物。研究表明，yerba mate具有抗氧化剂的潜力，可以帮助降低发生神经退行性疾病（如阿尔茨海默氏病（AD））的风险。众所周知，paraguariensis可以在带有铝（Al）的酸性土壤中生长，而铝在这些土壤中具有生物利用性。A1具有与神经系统疾病进展有关的神经毒性潜能。这项研究的目的是评估秀丽隐杆线虫菌株和副生马鞭草提取物中的铝和抗氧化剂的浓度，以评估副伤寒假单胞菌在AD病原学中的潜力。I.paraguariensis的结果在65°C和75°C的温度下进行的注入表明，在制备茶注入液时，两种温度之间相对于Al，甲基黄嘌呤，酚类化合物和类黄酮的存在无显着差异。另外，在Al的情况下，在两种温度下制备的提取物之间没有差异。长期暴露于两种因素后，秀丽隐杆线虫的行为参数发生了变化：I。paraguariensis提取物和Al。通过抗氧化剂水平以及乙酰胆碱酯酶（AChE）活性中的Al含量结果，可以观察到急性和慢性暴露于Al和Paraguariensis叶子提取物与野生型蠕虫非常相似。此外，我们可以观察到，长期暴露于巴拉圭I.叶片提取物和Al浓度的转基因菌株的结果均显示出AChE活性的增加。