Seven new bismuth(III) complexes derived from indole-carboxylic acids have been synthesised: five are homoleptic; [Bi(IAA)₃] B1, [Bi(IPA)₃] B2, [Bi(IBA)₃] B3, [Bi(MICA)₃] B4, [Bi(IGA)₃] B6, and two are heteroleptic [BiPh(MICA)₂] B5 (where IAA-H = 2-(1H-indol-3-yl)acetic acid, IPA-H = 3-(1H-indol-3-yl)propanoic acid, IBA-H = 4-(1H-indol-3-yl)butanoic acid, IGA-H = 2-(1H-indol-3-yl)-2-oxoacetic acid, and MICA-H = 1-methyl-1H-indole-3-carboxylic acid). All complexes were fully characterised by elemental analysis, infrared and mass-spectroscopy, and nuclear magnetic resonance (¹H, ¹³C) spectroscopy. Complex [BiPh(IGA)₂] B7 is structurally authenticated by X-ray crystallography as a dimer in the solid-state. The in-vitro anti-bacterial activity of the indole-carboxylic acids and their bismuth(III) complexes was assessed against Helicobacter pylori. While the acids were non-toxic at < 100 μg mL^− 1, all the bismuth compounds showed an MIC of 6.25 μg mL^− 1, indicating that the anti-bacterial activity is insensitive to the degree of substitution at the Bi(III) centre or the composition of the indole-carboxylate ligands. All compounds were further tested for their anti-parasitic activity against Leishmania major and for their toxicity towards mammalian cells. From the anti-parasitic studies, it was found that the heteroleptic bismuth(III) complexes are the most active, with B5 and B7 showing comparable activity to Amphotericin B, without any toxicity towards the mammalian cells at their effective concentration.

已合成了七种衍生自吲哚羧酸的新型铋（III）配合物：五种为均纯的；三类为高纯。[Bi（IAA）₃ ] B1，[Bi（IPA）₃ ] B2，[Bi（IBA）₃ ] B3，[Bi（MICA）₃ ] B4，[Bi（IGA）₃ ] B6和两个是杂合的[ BiPh（MICA）₂ ] B5（其中IAA- H  = 2-（1H-吲哚-3-基）乙酸，IPA- H  = 3-（1H-吲哚-3-基）丙酸，IBA- H  = 4 -（1H-吲哚-3-基）丁酸，IGA- H  = 2-（1H-吲哚-3-基）-2-氧乙酸和MICA- H ＝ 1-甲基-1H-吲哚-3-羧酸）。通过元素分析，红外和质谱以及核磁共振（¹ H，¹³ C）光谱对所有配合物进行了全面表征。配合物[BiPh（IGA）₂ ] B7在结构上通过X射线晶体学鉴定为固态的二聚体。评估了吲哚羧酸及其铋（III）配合物对幽门螺杆菌的体外抗菌活性。虽然酸是在<100微克毫升无毒^{- 1}，所有的铋化合物显示了6.25的MIC微克毫升^{- 1}，表明抗菌活性对Bi（III）中心的取代度或吲哚羧酸酯配体的组成不敏感。进一步测试了所有化合物对利什曼原虫的抗寄生虫活性以及对哺乳动物细胞的毒性。从抗寄生虫研究中发现，杂配铋（III）络合物活性最高，B5和B7具有与两性霉素B相当的活性，并且在其有效浓度下对哺乳动物细胞没有任何毒性。