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Poly (vinyl pyrrolidone)-lipid based hybrid nanoparticles for anti viral drug delivery
Chemistry and Physics of Lipids ( IF 3.4 ) Pub Date : 2017-11-10 , DOI: 10.1016/j.chemphyslip.2017.11.003
K.S. Joshy , S. Snigdha , George Anne , Kalarikkal Nandakumar , Pothen Laly. A. , Thomas Sabu

Zidovudine (AZT) is an antiviral drug with moderate solubility in water. It has limited application due to its short half life in vivo and consequent requirement for frequent administrations. To solve this problem, zidovudine loaded polyvinylpyrrolidone (PVP)/stearic acid (SA)-polyethylene glycol (PEG) nanoparticles (PSNPs) were developed.The hybrid nanoparticles were prepared by emulsification–solvent evaporation method. The physico chemical characterizations of the PSNPs was done by dynamic light scattering (DLS), transmission electron microscopy (TEM), and fourier transform infra-red spectroscopy (FT-IR). The in vitro release behavior and haemocompatibility studies were also performed. The in vitro cytotoxicity and cell uptake studies of the PSNPs were assessed in murine neuro-2a and HeLa cells. Our results revealed that the core shell PSNPs prepared from lipid and polymer led to significant improvement in cellular internalization. Therefore, it is envisaged that nanoparticles composed of lipid and polymer moieties may constitute a preferred embodiment for anti-viral drug delivery for use in HIV/AIDS therapy.



中文翻译:

基于聚乙烯吡咯烷酮-脂质的杂化纳米颗粒用于抗病毒药物的递送

齐多夫定(AZT)是在水中具有中等溶解度的抗病毒药物。由于其体内半衰期短,因此需要频繁给药,因此其应用受到限制。为了解决这个问题,开发了负载齐多夫定的聚乙烯吡咯烷酮(PVP)/硬脂酸(SA)-聚乙二醇(PEG)纳米颗粒(PSNPs)。通过乳化-溶剂蒸发法制备了杂化纳米颗粒。通过动态光散射(DLS),透射电子显微镜(TEM)和傅立叶变换红外光谱(FT-IR)对PSNP进行了物理化学表征。在体外也进行释放行为和血液相容性的研究。在体外在鼠神经2a和HeLa细胞中评估了PSNP的细胞毒性和细胞摄取研究。我们的结果表明,由脂质和聚合物制备的核壳PSNP可以显着改善细胞内在化。因此,设想由脂质和聚合物部分组成的纳米颗粒可以构成用于HIV / AIDS治疗的抗病毒药物递送的优选实施方案。

更新日期:2017-11-10
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