The sol-gel transition behavior and the degradation behavior of the nanocomposites consisting of laponite clay nanoparticles and poly(d,l-lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(d,l-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymers (laponite/PLGA-PEG-PLGA nanocomposites) were studied changing the LA/GA ratios of the PLGA blocks in the PLGA-PEG-PLGA. The thermo-responsive sol-gel transition at the physiological temperature (25–37 °C) was observed using the PLGA-PEG-PLGA with a high PEG/PLGA ratio of ∼0.8 regardless of the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). The decomposition rates of the laponite/PLGA-PEG-PLGA nanocomposites at 37 °C were regulated by adjusting the LA/GA ratios (LA/GA: 1.1, 4.0, and 8.8). Specifically, ∼45% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratio of 1.1, while ∼30% of the weight loss was observed after 10 days of the decomposition for the laponite/PLGA-PEG-PLGA nanocomposites with the LA/GA ratios of 4.0 and 8.8.

溶胶-凝胶转变行为和纳米复合材料的合成锂皂石选自粘土纳米颗粒和聚（的降解行为的d，l-丙交酯-共-乙交酯） - b -聚（乙二醇） - b -聚（d，L -丙交酯-共同研究了乙交酯（PLGA-PEG-PLGA）三嵌段共聚物（膨润土/ PLGA-PEG-PLGA纳米复合材料）的变化，以改变PLGA-PEG-PLGA中PLGA嵌段的LA / GA比。使用PLGA-PEG-PLGA观察到在生理温度（25-37°C）时具有热响应性的溶胶-凝胶转变，无论LA / GA的比率如何，PEG / PLGA的比率都很高，约为0.8（LA / GA： 1.1、4.0和8.8）。通过调节LA / GA的比例（LA / GA：1.1、4.0和8.8），可以调节Laponite / PLGA-PEG-PLGA纳米复合材料在37°C时的分解速率。具体而言，在LA / GA比为1.1的合成皂石/ PLGA-PEG-PLGA纳米复合材料分解10天后，观察到约45％的重量损失，而在30天的Laponite / PLGA-PEG-PLGA纳米复合材料经分解后约30％的重量损失。 LA / GA比为4.0和8.8的合成皂石/ PLGA-PEG-PLGA纳米复合材料的分解过程。