Viscosity control for concentrated protein solutions is very important for the manufacturability and drug delivery routes of many protein therapeutics of the pharmaceutical industry. Even though there are successful applications of colloidal theories to calculate or predict the viscosity of globular proteins with electrostatic repulsions, understanding concentrated protein solutions remains an open challenge for colloidal science. This is especially true when proteins have complicated interaction potentials and non-spherical shapes, such as monoclonal antibody proteins. This paper provides a brief review of the recent experimental and theoretical progress in understanding the viscosity of concentrated protein solutions with a focus on the experimental results.

浓缩蛋白质溶液的粘度控制对于制药行业许多蛋白质疗法的可制造性和药物传递途径非常重要。即使胶体理论已成功应用来计算或预测具有静电排斥力的球形蛋白质的粘度，但了解浓缩的蛋白质溶液仍是胶体科学面临的开放挑战。当蛋白质具有复杂的相互作用潜能和非球形形状时，尤其如此，例如单克隆抗体蛋白质。本文简要介绍了最近在理解浓缩蛋白溶液粘度方面的实验和理论进展，重点是实验结果。