BACKGROUND Modifiable lifestyle factors, such as diet quality, could reduce inflammation and improve quality of life (QOL) in breast cancer survivors, but data are inconclusive. OBJECTIVE To determine whether diet quality, as measured by Healthy Eating Index-2010 (HEI-2010) score, is associated with inflammation, health status, or functional outcomes affecting QOL in survivors of early-stage breast cancer. DESIGN This is a cross-sectional, secondary analysis of baseline data collected from breast cancer survivors after completion of primary therapy and before random assignment to a pilot nutritional intervention aimed at reducing side effects of aromatase inhibitor treatment. PARTICIPANTS/SETTING Participants were 44 postmenopausal women with stage I to III endocrine receptor-positive breast cancer receiving outpatient care at a midwestern cancer center between November 2011 and October 2013. MAIN OUTCOME MEASURES Primary outcomes were serum proinflammatory cytokines (interleukin-6 [IL-6], IL-17, and tumor necrosis factor-α receptor 2 [TNFR-2]). Secondary outcomes included QOL measured by the Stanford Health and Disability Questionnaire and the Functional Assessment of Cancer Therapy-Breast with Endocrine Subscale. STATISTICAL ANALYSES PERFORMED Pearson correlation coefficients (r) and linear regression models were used to evaluate the relationship of dietary variables with inflammatory cytokines and QOL measures. RESULTS A higher overall HEI-2010 score (healthier diet) was associated with lower IL-6 (r=-0.46; P=0.002) and TNFR-2 (r=-0.41; P=0.006); however, associations were attenuated by body mass index (BMI) (IL=6 [r=-0.26; P=0.10]; TNFR-2 [r=-0.30; P=0.06]). In women with prior chemotherapy, a higher HEI-2010 score was strongly associated with lower IL-6 (r=-0.67; P=0.009) and TNFR-2 (r=-0.59; P=0.03) after BMI adjustment. There were no significant correlations between HEI-2010 score and QOL measures after adjustment for BMI. CONCLUSIONS These data suggest the need for more rigorous investigation into the relationship of diet quality, BMI, and inflammation in breast cancer survivors.

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乳腺癌幸存者的饮食质量、炎症和生活质量：初步研究数据的横断面分析

背景可改变的生活方式因素，例如饮食质量，可以减少乳腺癌幸存者的炎症并提高生活质量 (QOL)，但数据尚无定论。目的 确定通过健康饮食指数 2010 (HEI-2010) 评分衡量的饮食质量是否与炎症、健康状况或影响早期乳腺癌幸存者 QOL 的功能结果相关。设计 这是对完成主要治疗后和随机分配到旨在减少芳香酶抑制剂治疗副作用的试点营养干预之前从乳腺癌幸存者收集的基线数据的横断面二次分析。参与者/地点 参与者是 44 名患有 I 至 III 期内分泌受体阳性乳腺癌的绝经后妇女，他们于 2011 年 11 月至 2013 年 10 月在中西部癌症中心接受门诊治疗。主要结果测量主要结果是血清促炎细胞因子（白细胞介素-6 6]、IL-17 和肿瘤坏死因子-α 受体 2 [TNFR-2]）。次要结果包括由斯坦福健康和残疾问卷测量的 QOL 和癌症治疗的功能评估 - 乳房与内分泌分量表。执行的统计分析 Pearson 相关系数 (r) 和线性回归模型用于评估饮食变量与炎性细胞因子和 QOL 测量的关系。结果 较高的 HEI-2010 总分（更健康的饮食）与较低的 IL-6 相关（r=-0.46；P=0。002) 和 TNFR-2 (r=-0.41；P=0.006)；然而，相关性被体重指数 (BMI) 减弱（IL=6 [r=-0.26；P=0.10]；TNFR-2 [r=-0.30；P=0.06]）。在接受过化疗的女性中，较高的 HEI-2010 评分与较低的 IL-6（r=-0.67；P=0.009）和 TNFR-2（r=-0.59；P=0.03）在 BMI 调整后密切相关。在调整 BMI 后，HEI-2010 评分与 QOL 测量值之间没有显着相关性。结论 这些数据表明需要对乳腺癌幸存者的饮食质量、BMI 和炎症之间的关系进行更严格的调查。009) 和 TNFR-2 (r=-0.59; P=0.03) 在 BMI 调整后。在调整 BMI 后，HEI-2010 评分与 QOL 测量值之间没有显着相关性。结论 这些数据表明需要对乳腺癌幸存者的饮食质量、BMI 和炎症之间的关系进行更严格的调查。009) 和 TNFR-2 (r=-0.59; P=0.03) 在 BMI 调整后。在调整 BMI 后，HEI-2010 评分与 QOL 测量值之间没有显着相关性。结论 这些数据表明需要对乳腺癌幸存者的饮食质量、BMI 和炎症之间的关系进行更严格的调查。