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Synthetic Cancer‐Targeting Innate Immune Stimulators Give Insights into Avidity Effects
ChemBioChem ( IF 3.2 ) Pub Date : 2018-01-26 , DOI: 10.1002/cbic.201700522
Anne C. Conibear 1 , André J. G. Pötgens 2 , Karine Thewes 1 , Claudia Altdorf 2 , Clarissa Hilzendeger 2 , Christian F. W. Becker 1
Affiliation  

Multivalent and multispecific molecules based on cancer‐targeting and immune‐stimulatory peptide components joined by flexible linkers were synthesized by solid‐phase peptide synthesis and chemoselective ligations to explore avidity effects on cancer and immune cells.
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中文翻译:

针对合成癌症的先天免疫刺激剂可深入了解亲和力效应

通过固相肽合成和化学选择性连接,合成了基于癌症靶向和免疫刺激性肽成分(通过柔性接头连接)的多价和多特异性分子,以研究其对癌症和免疫细胞的亲和力影响。
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更新日期:2018-01-26
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