The cover feature picture shows the reaction catalyzed by 2‐haloacrylate hydratase. This flavin‐dependent enzyme utilizes the reduced form of the flavin to catalyze a dehalogenation/hydration reaction via a covalent flavin intermediate. In our paper, we characterize this intermediate and propose a mechanism of action for this new member of the noncanonical flavoenzyme family. More information can be found in the communication by J. J. Tanner, P. Sobrado, et al. on page 53 in Issue 1, 2018 (DOI: 10.1002/cbic.201700594).

中文翻译：

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封面人物：非典型黄素酶催化的非氧化还原脱卤反应中的黄素-N5共价中间体

封面特征图片显示了2-卤代丙烯酸酯水合酶催化的反应。这种黄素依赖性酶利用黄素的还原形式通过共价黄素中间体催化脱卤/水合反应。在我们的论文中，我们对这种中间体进行了表征，并提出了针对非经典黄素酶家族这一新成员的作用机制。在J. J. Tanner，P。Sobrado等人的来文中可以找到更多信息。关于第53页中第1期，2018（：10.1002 / cbic.201700594 DOI）。