Treatment of a solution of 9-benzyl or 9-phenyl 6-iodopurine in dichloromethane with an ethereal solution of ethylmagnesium bromide at ambient temperature generates the corresponding purin-6-yl magnesium halides which react with aldehydes to give carbinols in 55–80% yield. Performing the same procedure with THF as solvent gave carbinols in much lower yields (≤15%).

中文翻译：

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在二氯甲烷中通过金属-卤素交换制备 Purin-6-yl 卤化镁的改进途径

在室温下用乙基溴化镁的醚溶液处理 9-苄基或 9-苯基 6-碘嘌呤的二氯甲烷溶液，生成相应的 6-基卤化嘌呤镁，与醛反应生成甲醇，产率为 55-80% . 使用 THF 作为溶剂执行相同的程序，得到的甲醇产率要低得多 (≤15%)。