The microarray titre plate remains a fundamental workhorse in genomic, proteomic and cellomic analyses that underpin the drug discovery process. Nevertheless, liquid handling technologies for sample dispensing, processing and transfer have not progressed significantly beyond conventional robotic micropipetting techniques, which are not only at their fundamental sample size limit, but are also prone to mechanical failure and contamination. This is because alternative technologies to date suffer from a number of constraints, mainly their limitation to carry out only a single liquid operation such as dispensing or mixing at a given time, and their inability to address individual wells, particularly at high throughput. Here, we demonstrate the possibility for true sequential or simultaneous single- and multi-well addressability in a 96-well plate using a reconfigurable modular platform from which MHz-order hybrid surface and bulk acoustic waves can be coupled to drive a variety of microfluidic modes including mixing, sample preconcentration and droplet jetting/ejection in individual or multiple wells on demand, thus constituting a highly versatile yet simple setup capable of improving the functionality of existing laboratory protocols and processes.

中文翻译：

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即插即用：使用模块化混合声波技术的微阵列板的多模式个体可寻址性

微阵列滴定板仍然是支持药物发现过程的基因组，蛋白质组和细胞组学分析的基础。然而，用于样品分配，处理和转移的液体处理技术没有比传统的机器人微量移液技术取得显着进步，传统的机器人微量移液技术不仅处于其基本的样品尺寸极限，而且还易于发生机械故障和污染。这是因为迄今为止的替代技术受到许多限制，主要是它们在给定时间只能进行单个液体操作（例如分配或混合）的限制，以及无法处理单个孔，特别是在高通量的情况下。这里，