The mechanisms by which chronic stress promote the development of pancreatic ductal adenocarcinoma (PDAC) are poorly defined. In this issue of Cancer Cell, Todoric et al. discover a role for impaired autophagy in the development of PDAC through p62-mediated activation of NRF2.

中文翻译：

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强调PanIN：NRF2推动边缘。

慢性应激促进胰腺导管腺癌（PDAC）发展的机制尚不清楚。在本期《癌细胞》中，Todoric等人。通过p62介导的NRF2激活，发现自噬受损在PDAC发育中的作用。