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Male homosexuality and maternal immune responsivity to the Y-linked protein NLGN4Y
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2018-01-09 00:00:00 , DOI: 10.1073/pnas.1705895114
Anthony F Bogaert 1, 2 , Malvina N Skorska 2, 3 , Chao Wang 4 , José Gabrie 5 , Adam J MacNeil 5 , Mark R Hoffarth 2 , Doug P VanderLaan 3, 6 , Kenneth J Zucker 7 , Ray Blanchard 7
Affiliation  

We conducted a direct test of an immunological explanation of the finding that gay men have a greater number of older brothers than do heterosexual men. This explanation posits that some mothers develop antibodies against a Y-linked protein important in male brain development, and that this effect becomes increasingly likely with each male gestation, altering brain structures underlying sexual orientation in their later-born sons. Immune assays targeting two Y-linked proteins important in brain development—protocadherin 11 Y-linked (PCDH11Y) and neuroligin 4 Y-linked (NLGN4Y; isoforms 1 and 2)—were developed. Plasma from mothers of sons, about half of whom had a gay son, along with additional controls (women with no sons, men) was analyzed for male protein-specific antibodies. Results indicated women had significantly higher anti-NLGN4Y levels than men. In addition, after statistically controlling for number of pregnancies, mothers of gay sons, particularly those with older brothers, had significantly higher anti-NLGN4Y levels than did the control samples of women, including mothers of heterosexual sons. The results suggest an association between a maternal immune response to NLGN4Y and subsequent sexual orientation in male offspring.

中文翻译:

男性同性恋和母体对 Y 连锁蛋白 NLGN4Y 的免疫反应

我们对同性恋男性的哥哥数量比异性恋男性更多的免疫学解释进行了直接测试。这种解释认为,一些母亲会产生针对一种对男性大脑发育很重要的 Y 连锁蛋白的抗体,并且这种效应在每个男性妊娠中变得越来越可能,从而改变了他们后来出生的儿子性取向的大脑结构。开发了针对两种对大脑发育很重要的 Y 连锁蛋白——原钙粘蛋白 11 Y 连锁蛋白 (PCDH11Y) 和神经胶质 4 Y 连锁蛋白 (NLGN4Y; 亚型 1 和 2) 的免疫测定。分析了来自儿子母亲(其中大约一半有一个同性恋儿子)以及其他对照(没有儿子的女性,男性)的血浆中的男性蛋白质特异性抗体。结果表明,女性的抗 NLGN4Y 水平显着高于男性。此外,在对怀孕次数进行统计控制后,同性恋儿子的母亲,尤其是有哥哥的母亲,其抗 NLGN4Y 水平显着高于女性对照样本,包括异性恋儿子的母亲。结果表明母体对 NLGN4Y 的免疫反应与随后的雄性后代性取向之间存在关联。
更新日期:2018-01-10
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