This study describes the synthesis, lipophilicity and in vitro antimicrobial assays of 15 new hydrazide–hydrazones of isonicotinic acid. New derivatives were obtained on the basis of the condensation reaction of isonicotinic acid hydrazide with different aromatic aldehydes. The chemical structure of synthesized compounds was confirmed by spectral methods. Experimental lipophilicity of new isonicotinic acid derivatives was determined using reversed‐phase thin‐layer chromatography. All synthesized compounds were subjected to in vitro antimicrobial assays against reference strains of Gram‐positive bacteria, Gram‐negative bacteria and fungi belonging to Candida spp. Some of the synthesized hydrazide–hydrazones proved to be significant antibacterial compounds and more potent than commonly used chemotherapeutic agents.

中文翻译：

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异烟酸的新酰肼-hydr：合成，亲脂性和体外抗菌筛选

这项研究描述了15种新的异烟酸酰肼－hydr酮的合成，亲脂性和体外抗菌测定。在异烟酸酰肼与不同芳族醛的缩合反应的基础上，获得了新的衍生物。通过光谱方法证实了合成化合物的化学结构。使用反相薄层色谱法测定了新的异烟酸衍生物的实验亲脂性。所有合成的化合物均接受了针对念珠菌的革兰氏阳性菌，革兰氏阴性菌和真菌的参考菌株的体外抗菌测定spp。一些合成的酰肼-酮被证明是重要的抗菌化合物，并且比常用的化学治疗剂更有效。