The three‐component reaction for the synthesis of 2‐arylthiophenes has been developed. Easily available arylacetaldehydes, 1,3‐dicarbonyls, and elemental sulfur were directly assembled through cascade condensation/ annulation under base conditions. The present protocol provides a facile entry to 2,3,5‐trisubstituted thiophenes with moderate to excellent yields and good functional group tolerance.

中文翻译：

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通过芳基乙醛，元素硫和1,3-二羰基化合物的三组分组装一锅合成2,3,5-三取代的噻吩

已经开发了用于合成2-芳基噻吩的三组分反应。容易获得的芳基乙醛，1,3-二羰基和元素硫在碱性条件下通过级联缩合/环合反应直接组装。本协议提供了2,3,5-三取代噻吩的简便入门方法，具有中等至优异的收率和良好的官能团耐受性。