当前位置: X-MOL 学术Angew. Chem. Int. Ed. › 论文详情
ortho-Directing Chromium Arene Complexes as Efficient Mediators for Enantiospecific C(sp2)–C(sp3) Cross-Coupling Reactions
Angewandte Chemie International Edition ( IF 12.102 ) Pub Date : 2018-01-03 , DOI: 10.1002/anie.201711816
Raphael Bigler, Varinder K. Aggarwal

Abstract

A new strategy for the coupling of a broad scope of electronically diverse aromatics to boronic esters is reported. The coupling sequence, which relies on the directed ortho-lithiation of chromium arene complexes followed by boronate formation and oxidation, occurs with complete ortho-selectivity and enantiospecificity to give the coupling products in excellent yields and with high functional group tolerance. An intermediate chromium arene boronate complex was characterized by X-ray, NMR, and IR experiments to elucidate the reaction mechanism.

Thumbnail image of graphical abstract

The C(sp2)–C(sp3) coupling of chromium arene complexes with boronic esters is reported. After ortho-selective lithiation of the aromatic and boronate formation, oxidation at the electron-rich chromium center with I2 triggers the 1,2-migration and Bpin elimination to directly afford the decomplexed ortho-coupled products in high yield and with complete enantiospecificity.

更新日期:2018-01-03

 

分享到
评论: 0
期刊列表
深圳大学可拉伸电子研究中心招聘专职研究员
西湖大学邓力教授课题组招聘启事
天合科研
【问答】请问离子液体的TGA分析有哪些特征?
2017年中科院JCR分区化学大类列表
试剂库存管理
化合物查询
down
wechat
bug