Undifferentiated pleomorphic sarcomas, myxofibrosarcomas, and malignant peripheral nerve sheath tumors are characterized by complex genomic characteristics and aggressive clinical behavior. Recent advances in the understanding of the pathogenesis of these tumors may allow for the development of more-effective innovative therapeutic strategies, including immunotherapies. This review describes the current knowledge of the epidemiology, clinical presentation, treatment, and pathogenesis of these tumors and highlights ongoing and future research.

中文翻译：

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未分化多形性肉瘤、粘液纤维肉瘤和恶性外周神经鞘瘤的生物学和治疗：最新技术和前景

未分化多形性肉瘤、粘液纤维肉瘤和恶性周围神经鞘瘤的特点是复杂的基因组特征和侵袭性的临床行为。对这些肿瘤发病机制的了解的最新进展可能有助于开发更有效的创新治疗策略，包括免疫疗法。本综述描述了这些肿瘤的流行病学、临床表现、治疗和发病机制的当前知识，并重点介绍了正在进行和未来的研究。