Microcapsules with nanoporous membranes can regulate transmembrane transport in a size-dependent fashion while protecting active materials in the core from the surrounding, and are thereby useful as artificial cell models, carriers for cells and catalysts, and microsensors. In this work, we report a pragmatic microfluidic approach to producing such semipermeable microcapsules with precise control of the cutoff threshold of permeation. Using a homogeneous polymerization mixture for the polymerization-induced microphase separation (PIMS) process as the oil phase of water-in-oil-in-water (W/O/W) double emulsions, a densely cross-linked shell composed of a bicontinuous nanostructure that percolates through the entire thickness is prepared, which serves as a template for a monolithic nanoporous membrane of microcapsules with size-selective permeability. We demonstrate that the nanopores with precisely controlled size by the block polymer self-assembly govern molecular diffusion through the membrane and render manipulation of the cutoff threshold.

中文翻译：

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具有嵌段聚合物模板的纳米多孔膜的半透性微胶囊

具有纳米孔膜的微胶囊可以以尺寸依赖性的方式调节跨膜运输，同时保护核心中的活性物质不受周围环境的影响，因此可用作人造细胞模型，细胞和催化剂的载体以及微传感器。在这项工作中，我们报告了一种实用的微流控方法来生产这种半透性微胶囊，并精确控制渗透的截止阈值。使用均相的聚合混合物作为水包油型水（W / O / W）双乳液的油相进行聚合诱导的微相分离（PIMS）过程，由双连续结构组成的致密交联壳制备了渗入整个厚度的纳米结构，该结构用作具有尺寸选择渗透性的微囊整体纳米多孔膜的模板。