This study demonstrates that the annulation of a tetrahydro-1,2-oxazine ring can be realized via bifunctional catalysis, employing nitroolefins and a recently introduced group of aminooxylating reagents as starting materials. The developed cascade reactivity proceeds in a sequence aza-Michael–Michael reaction. The target products, bearing three contiguous stereocenters, have been obtained with high yields (up to 97%) and excellent stereocontrol (>20 : 1 dr, up to 99.5 : 0.5 er).

中文翻译：

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四氢1,2-恶嗪的立体控制合成中的双功能催化†

这项研究表明，使用硝基烯烃和最近引入的一组氨基氧化试剂作为起始原料，可以通过双功能催化实现四氢1,2-恶嗪环的环化。所发展的级联反应性按序列aza-Michael-Michael反应进行。获得了具有三个连续立体中心的目标产品，具有高产率（高达97％）和出色的立体控制（> 20：1 dr，高达99.5：0.5 er）。