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Determination and Correlation of Dipyridamole p-Toluene Sulfonate Solubility in Seven Alcohol Solvents and Three Binary Solvents
Journal of Chemical & Engineering Data ( IF 2.6 ) Pub Date : 2017-12-08 00:00:00 , DOI: 10.1021/acs.jced.7b00825
Mengya Li 1, 2 , Shiyuan Liu 1, 2 , Si Li 1, 2 , Yang Yang 1, 2 , Yingdan Cui 1, 2 , Junbo Gong 1, 2, 3
Affiliation  

The solubility of dipyridamole p-toluene sulfonate in seven monosolvents (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, isobutanol, 2-butanol) and three different binary solvents (methanol + ethanol, methanol + 1-propanol, methanol + 1-butanol) was measured by a gravimetric method at temperatures ranging from 288.15 to 328.15 K. The experimental results indicate that the solubility of dipyridamole p-toluene sulfonate increases with increasing temperature while showing negative correlation with the mole fraction of organic solvents (ethanol, 1-propanol, 1-butanol) at a given temperature in binary solvents. The Apelblat model, the CNIBS/R-K model, and the modified version of Jouyban-Acree models (the Apel-JA equation) were used to correlate the experimental data, and the calculated results of above models were found to agree well with the experimental data.

中文翻译:

双嘧达莫对甲苯磺酸盐在7种醇溶剂和3种二元溶剂中的溶解度测定及相关性

双嘧达莫对甲苯磺酸盐在七种单溶剂(甲醇,乙醇,1-丙醇,2-丙醇,1-丁醇,异丁醇,2-丁醇)和三种不同的二元溶剂(甲醇+乙醇,甲醇+ 1-丙醇,甲醇+ 1-丁醇)的重量法在288.15至328.15 K范围内进行了测量。实验结果表明,双嘧达莫对甲苯磺酸盐的溶解度随温度的升高而增加,但与有机溶剂的摩尔分数呈负相关关系(乙醇,1-丙醇,1-丁醇)在给定温度下的二元溶剂中。使用Apelblat模型,CNIBS / RK模型和Jouyban-Acree模型的修改版本(Apel-JA方程)来关联实验数据,
更新日期:2017-12-10
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