In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.

中文翻译：

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母乳寡糖对无乳链球菌、金黄色葡萄球菌和鲍曼不动杆菌的抗菌和抗菌活性

在之前的一项研究中，我们报道了从五个供体牛奶样品中分离出的人乳寡糖 (HMO) 对无乳链球菌（也称为 B 组链球菌或 GBS）具有抗菌和抗生物膜活性。在这里，我们通过筛选来自 14 名新供体的 HMO，针对三种 GBS 菌株和两种对儿童健康特别感兴趣的 ESKAPE 病原体，金黄色葡萄球菌和鲍曼不动杆菌，对抗菌和抗生物膜活性进行更广泛的评估。生长和生物膜测定表明，来自这些新供体的 HMO 对所有三种 GBS 菌株均具有抗菌和抗生物膜活性，对耐甲氧西林金黄色葡萄球菌具有抗生物膜活性菌株 USA300，以及对鲍曼不动杆菌菌株 ATCC 19606 的抗菌活性。