A causal relationship between target activity modulation by small molecules and phenotypic consequence is the cornerstone of chemical biology and drug discovery. Here we articulate elements of translational chemical biology, as guideposts to ensure the appropriate use of chemical probes and the conclusions drawn from cellular studies with these molecules.

中文翻译：

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转化化学生物学的要素

小分子对靶标活性的调节与表型结果之间的因果关系是化学生物学和药物发现的基础。在这里，我们明确阐述翻译化学生物学的要素，以确保适当使用化学探针以及使用这些分子进行细胞研究得出的结论为指导。