Inflammatory signals can activate hematopoietic stem cells (HSCs), but how HSCs regain quiescence after stress is unclear. In this issue of Cell Stem Cell, Chen et al. (2017) delineate an elegant histamine-dependent feedback mechanism through which myeloid bone marrow cells restore quiescence of myeloid-biased HSCs, with implications for blood disorders, aging, and immunity.

中文翻译：

---

压力后保存干细胞。

炎症信号可以激活造血干细胞（HSC），但尚不清楚应激后HSC如何恢复静止。在本期《细胞干细胞》中，Chen等人。（2017）描绘了一种优雅的依赖组胺的反馈机制，通过该机制，髓样骨髓细胞恢复了由髓样偏向的HSC的静止状态，对血液疾病，衰老和免疫力有影响。