Six new compounds, aristoloxazine A (1), aristoloxazine B (2), 7-methoxytaliscanine (3), humul-7-en-1,4,11-triol (4), 8-hydroxy-β-logipinene (5), and 1β-hydroxy-4(14)-eudesmene (6), corresponding to two sulfur-containing aristoloxazines (1 and 2), an aristolactam (3), and three sesquiterpenes (4–6) were isolated, along with 26 known compounds, from the roots of Aristolochia orbicularis. The structures of the new compounds were established based on their spectroscopic and spectrometric data and in the case of aristoloxazine A (1) by single-crystal X-ray crystallography. This is the first report of sulfur-containing aristoloxazines from a natural source. Furthermore, aristoloxazine A (1) was found to possess potent in vitro antimicrobial activity against all resistant Staphylococcus aureus and several fungal strains in which it was evaluated.

中文翻译：

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含硫马兜铃根和其他成分的马兜铃马齿根

六种新化合物，马兜铃嗪A（1），马兜铃嗪B（2），7-甲氧基taliscanine （3），humul-7-en-1,4,11-三醇（4），8-羟基-β-logipinene（5） ，和1β-羟基-4（14）-eudesmene（6），分别对应于两个含硫的马兜铃嗪（1和2），马兜铃内酰胺（3）和三个倍半萜（4 – 6），以及已知的26种化合物，来自马兜铃马兜铃的根。根据新化合物的光谱学和光谱数据，以及马兜铃嗪A（1）通过单晶X射线晶体学。这是来自自然来源的含硫马兜铃嗪的首次报道。此外，发现马兜铃嗪A（1）对所有抗药性金黄色葡萄球菌和几种真菌菌株均具有有效的体外抗菌活性。