A series of tellurides was evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) carbonic anhydrase isoforms hCA I, II, IV, VII and IX, involved in a variety of diseases, including glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors. These compounds, which are the first tellurium-containing derivatives acting as inhibitors of carbonic anhydrase enzymes, showed effective inhibition against all isoforms investigated and some of them were selective for inhibiting the cytosolic or the membrane-bound CAs. Thus, these carbonic anhydrase inhibitors are interesting leads for the development of isoform-selective inhibitors.

评估了一系列碲化物作为抗人（h）碳酸酐酶同工型hCA I，II，IV，VII和IX的碳酸酐酶（CA，EC 4.2.1.1）抑制剂，涉及多种疾病，包括青光眼，色素性视网膜炎，癫痫病，关节炎和肿瘤。这些化合物是最早的充当碳酸酐酶抑制剂的含碲衍生物，对所研究的所有同工型均显示出有效的抑制作用，其中某些对抑制胞质或膜结合CA具有选择性。因此，这些碳酸酐酶抑制剂是开发同工型选择性抑制剂的有趣线索。