The postsynaptic proteome of excitatory synapses comprises ~1,000 highly conserved proteins that control the behavioral repertoire, and mutations disrupting their function cause >130 brain diseases. Here, we document the composition of postsynaptic proteomes in human neocortical regions and integrate it with genetic, functional and structural magnetic resonance imaging, positron emission tomography imaging, and behavioral data. Neocortical regions show signatures of expression of individual proteins, protein complexes, biochemical and metabolic pathways. We characterized the compositional signatures in brain regions involved with language, emotion and memory functions. Integrating large-scale GWAS with regional proteome data identifies the same cortical region for smoking behavior as found with fMRI data. The neocortical postsynaptic proteome data resource can be used to link genetics to brain imaging and behavior, and to study the role of postsynaptic proteins in localization of brain functions.

中文翻译：

---

人类新皮质区域突触后蛋白的蛋白质组学分析。

兴奋性突触的突触后蛋白质组包含约 1,000 种高度保守的蛋白质，这些蛋白质控制着行为库，而破坏其功能的突变会导致超过 130 种脑部疾病。在这里，我们记录了人类新皮质区域中突触后蛋白质组的组成，并将其与遗传、功能和结构磁共振成像、正电子发射断层扫描成像和行为数据相结合。新皮质区域显示单个蛋白质、蛋白质复合物、生化和代谢途径的表达特征。我们描述了与语言、情感和记忆功能相关的大脑区域的成分特征。将大规模 GWAS 与区域蛋白质组数据相结合，确定了与 fMRI 数据发现的吸烟行为相同的皮层区域。