The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

中文翻译：

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衰老胰腺中的转录噪声和体细胞突变。

胰腺β细胞异质性的潜在机制和功能意义是研究的重点领域。在最近的Cell论文中，Enge及其同事（2017）对人胰腺细胞进行了单细胞RNA测序，并得出结论，随着年龄的增长，胰腺细胞在转录上会变得嘈杂并积累体细胞突变。