Abstract Poly Lactic Acid (PLA) nanofiber scaffold has enjoyed great interest as a candidate bioactive material for tissue regeneration. However, the hydrophobic nature of PLA and its weak mechanical properties with poor ductility and low strength hinder its practical applications. In this study, coaxial electrospinning was used to fabricate core-shell composite nanofibers with PLA in the core and PVA in the shell with significant enhancements in the surface wetting and mechanical properties. More specifically, the core/shell-structured PLA/PVA nanofiber mat exhibited excellent hydrophilic properties with a water contact angle of 27 ± 1.5° compared to 110° ± 2.5° for pristine PLA. Moreover, the fabricated composite nanofibers displayed nearly 254% and 175% increase in tensile strength and strain at failure, respectively, compared to pristine PLA (14.5 MPa vs. 4.1 MPa for tensile strength and 110% vs. 40% for ductility). The coaxial electrospun PLA(core)/PVA(shell) nanofibers also showed suitable properties for proliferation, and attachment of human embryonic kidney cells (HEK-293). These excellent combined mechanical, surface wetting, and cytocompatibility properties clearly demonstrate the potential applications of the synthetic core-shell PLA/PVA composite nanofibers in biomedical and tissue regeneration.

中文翻译：

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通过同轴静电纺丝制备聚乳酸和聚乙烯醇核壳结构纳米纤维用于组织工程

摘要 聚乳酸 (PLA) 纳米纤维支架作为组织再生的候选生物活性材料受到了极大的关注。然而，PLA的疏水性及其弱的机械性能、较差的延展性和低强度阻碍了其实际应用。在这项研究中，同轴静电纺丝被用来制造核壳型复合纳米纤维，其核为 PLA，壳为 PVA，其表面润湿性和机械性能显着增强。更具体地说，核/壳结构的 PLA/PVA 纳米纤维垫表现出优异的亲水性，水接触角为 27±1.5°，而原始 PLA 的水接触角为 110°±2.5°。此外，制造的复合纳米纤维在断裂时的拉伸强度和应变分别增加了近 254% 和 175%，与原始 PLA 相比（拉伸强度为 14.5 MPa 对 4.1 MPa，延展性为 110% 对 40%）。同轴电纺 PLA（核）/PVA（壳）纳米纤维还显示出适合人胚胎肾细胞 (HEK-293) 增殖和附着的特性。这些优异的综合机械、表面润湿和细胞相容性特性清楚地证明了合成核壳 PLA/PVA 复合纳米纤维在生物医学和组织再生中的潜在应用。