In this work, a copper sulfide nanoflakes–reduced graphene oxide (rGO/CuSNFs) nanocomposite has been successfully synthesized via one-pot hydrothermal treatment, where the reduction of GO and in situ generation of CuS nanoflakes occurred simultaneously. Subsequently, a nonenzymatic electrochemical sensor was fabricated based on the disposable rGO/CuSNFs nanocomposite for the highly sensitive and selective detection of glucose. The prepared rGO/CuSNFs nanocomposite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectrometry (EDX), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy, respectively. Under optimized conditions, the prepared enzymeless sensor exhibited remarkable catalytic activity toward the glucose oxidation with a fast response time of <6 s, a wide linear range from 1 to 2000 μM, a high sensitivity of 53.5 μM (cm² mM)⁻¹ and a low detection limit of 0.19 μM. Furthermore, the rGO/CuSNFs/GCE also showed the great reproducibility, the long-term storage stability and the excellent anti-interference ability for glucose sensing. In addition, the as-prepared sensor was applied to detect glucose in human urine and blood serum samples with satisfactory results, indicating that the rGO/CuSNFs nanocomposite is an extremely promising material for non-enzymatic glucose sensing in practical samples.

中文翻译：

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基于CuS纳米片减少的氧化石墨烯纳米复合材料的非酶促葡萄糖传感器†

在这项工作中，通过一锅水热处理成功地合成了硫化铜纳米薄片-氧化石墨烯（rGO / CuSNFs）纳米复合材料，其中GO的还原和原位还原CuS纳米薄片的生成同时发生。随后，基于一次性rGO / CuSNFs纳米复合材料制造了一种非酶电化学传感器，用于葡萄糖的高灵敏度和选择性检测。通过透射电子显微镜（TEM），扫描电子显微镜（SEM），能量色散X射线光谱（EDX），X射线衍射（XRD）和傅里叶变换红外（FTIR）光谱对制备的rGO / CuSNFs纳米复合材料进行了表征，分别。在优化的条件下，制备的无酶传感器对葡萄糖氧化表现出显着的催化活性，响应时间<6 s，线性范围从1到2000μM，灵敏度高53.5μM（cm ² mM）^-1低检测限为0.19μM。此外，rGO / CuSNFs / GCE还显示出良好的重现性，长期存储稳定性和出色的葡萄糖传感抗干扰能力。此外，所制备的传感器用于人尿和血清样品中的葡萄糖检测，结果令人满意，表明rGO / CuSNFs纳米复合材料是用于实际样品中非酶促葡萄糖传感的极有前途的材料。