当前位置: X-MOL 学术Phys. Life Rev. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses
Physics of Life Reviews ( IF 11.7 ) Pub Date : 2017-06-21 , DOI: 10.1016/j.plrev.2017.06.016
Bo Cheng 1 , Min Lin 1 , Guoyou Huang 1 , Yuhui Li 1 , Baohua Ji 2 , Guy M Genin 3 , Vikram S Deshpande 4 , Tian Jian Lu 1 , Feng Xu 1
Affiliation  

Cells in vivo reside within complex microenvironments composed of both biochemical and biophysical cues. The dynamic feedback between cells and their microenvironments hinges upon biophysical cues that regulate critical cellular behaviors. Understanding this regulation from sensing to reaction to feedback is therefore critical, and a large effort is afoot to identify and mathematically model the fundamental mechanobiological mechanisms underlying this regulation. This review provides a critical perspective on recent progress in mathematical models for the responses of cells to the biophysical cues in their microenvironments, including dynamic strain, osmotic shock, fluid shear stress, mechanical force, matrix rigidity, porosity, and matrix shape. The review highlights key successes and failings of existing models, and discusses future opportunities and challenges in the field.



中文翻译:

生物物理微环境的细胞机械传感:细胞反应生物物理调节数学模型的综述

体内细胞存在于由生化和生物物理线索组成的复杂微环境中。细胞及其微环境之间的动态反馈取决于调节关键细胞行为的生物物理线索。因此,理解这种从感知到反应再到反馈的调节至关重要,并且正在付出巨大的努力来识别和数学模拟这种调节背后的基本机械生物学机制。这篇综述为细胞对其微环境中生物物理线索的反应数学模型的最新进展提供了一个重要的视角,包括动态应变、渗透休克、流体剪切应力、机械力、基质刚性、孔隙率和基质形状。该评论强调了现有模型的主要成功和失败,并讨论了该领域未来的机遇和挑战。

更新日期:2017-06-21
down
wechat
bug