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Towards sustainable kinetic resolution, a combination of bio-catalysis, flow chemistry and bio-based solvents
Green Chemistry ( IF 9.8 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c7gc03177g Andree Iemhoff 1, 2, 3, 4, 5 , James Sherwood 1, 2, 3, 4 , Con R. McElroy 1, 2, 3, 4 , Andrew J. Hunt 1, 2, 3, 4, 6
Green Chemistry ( IF 9.8 ) Pub Date : 2017-12-01 00:00:00 , DOI: 10.1039/c7gc03177g Andree Iemhoff 1, 2, 3, 4, 5 , James Sherwood 1, 2, 3, 4 , Con R. McElroy 1, 2, 3, 4 , Andrew J. Hunt 1, 2, 3, 4, 6
Affiliation
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The esterification of 2-phenylpropionic acid was investigated as a model system for enzyme catalysed (CALB, Novozyme 435) reactions in bio-based solvents. A multi-parameter correlation taking into account solvent parameters was developed to explain experimental observations. A continuous flow process using p-cymene as the solvent was operated over several weeks, thus combining a sustainable solvent and flow chemistry for kinetic resolution.
中文翻译：
为了实现可持续的动力学拆分，将生物催化，流化学和生物基溶剂相结合
研究了2-苯基丙酸的酯化反应，作为在生物基溶剂中进行酶催化（CALB，Novozyme 435）反应的模型系统。考虑到溶剂参数的多参数相关性被开发来解释实验观察。使用对甲基异丙基苯作为溶剂的连续流动过程进行了数周，因此将可持续的溶剂和流动化学相结合以实现动力学拆分。
更新日期：2018-01-02
中文翻译：
为了实现可持续的动力学拆分，将生物催化，流化学和生物基溶剂相结合
研究了2-苯基丙酸的酯化反应，作为在生物基溶剂中进行酶催化（CALB，Novozyme 435）反应的模型系统。考虑到溶剂参数的多参数相关性被开发来解释实验观察。使用对甲基异丙基苯作为溶剂的连续流动过程进行了数周，因此将可持续的溶剂和流动化学相结合以实现动力学拆分。
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