The selective Passerini reactions of 4-formylbenzoic acid and 4-isocyanobenzoic acid with aliphatic isocyanides and aldehydes were utilized to synthesize sequence-defined uniform macromolecules. Our strategy does not involve any protecting groups or reactive group transformation steps and allows direct and consecutive propagation of sequence in each step. Introduction of diverse side groups by using different aliphatic components provided a range of sequence-defined uniform macromolecules in high yield and gram scale. The strategy also allows further Passerini self-coupling or cross-coupling of the formed sequences with other small molecules, affording polymers with up to 5098.3 Da and 20 side groups. Thus, this strategy will show promise for more efficient synthesis of new sequence-defined macromolecules.

中文翻译：

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通过选择性帕塞里尼反应连续单加成均匀大分子的双序列控制

4-甲酰基苯甲酸和4-异氰基苯甲酸与脂肪族异氰化物和醛的选择性帕塞里尼反应被用于合成序列定义的均匀大分子。我们的策略不涉及任何保护基团或反应性基团转化步骤，并允许在每个步骤中直接和连续传播序列。通过使用不同的脂肪族成分引入不同的侧基提供了一系列高产率和克级的序列定义的均匀大分子。该策略还允许形成的序列与其他小分子进一步进行 Passerini 自偶联或交叉偶联，从而提供具有高达 5098.3 Da 和 20 个侧基的聚合物。因此，该策略将有望更有效地合成新的序列定义的大分子。