Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria.

中文翻译：

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malERA：关于消除和消除疟疾的基础科学和扶持技术的最新研究议程。

基础科学具有揭示疾病生物学机制的巨大力量，从而为新的有效干预措施铺平了道路。认识到这种力量，2011年《消除疟疾研究议程》将基础研究的关键优先事项包括在内，如果得以实现，将有助于加快消除和根除疾病的进程。疟疾根除研究议程（malERA）基础科学和使能技术咨询小组审查了未来研究的进展，持续的挑战和主要机遇。这些建议来自已出版和未出版材料的文献以及malERA Refresh咨询小组的审议。这些区域涵盖了人类宿主和按蚊载体中疟原虫生命周期的多个方面，包括关键的，关于寄生虫传播，肝脏中人类感染，无性阶段生物学和疟疾持续存在的未解决问题。我们相信，一种涵盖人类免疫学，寄生虫学和昆虫学的综合方法，以及利用新兴生物医学技术，将为解决这些问题并最终减轻全球疟疾负担提供最佳途径。